Stockwinners Market Radar for May 18, 2022 - Earnings, Upgrades downgrades, option trades, Best Stock Advisory Service

DNA

Hot Stocks

20:40 EDT Cathie Wood's ARK Investment bought 4.7M shares of Ginkgo Bioworks today
LAD

Hot Stocks

19:48 EDT Lithia & Driveway director sells $1.53M in common stock - In a regulatory filing, Lithia & Driveway disclosed that its director Sidney Deboer sold 5K share of common stock on May 17th in a total transaction size of $1.53M.
FYBR

Hot Stocks

18:40 EDT Frontier Communications plans to exceed fiber build target in 2022 - Frontier Communications plans to exceed its target of 1 million fiber locations in 2022, according to CFO Scott Beasley speaking at the MoffettNathanson Media Communications Summit. Beasley announced that Frontier plans to accelerate the fiber build, and now expects to exceed its 2022 build target of 1 million fiber locations by an additional 100,000-200,000 locations. Frontier continues to expect a cost of $900-1000 per passing for its Wave 2 build plan. The recent closing of $1.2B in additional debt puts Frontier in position to accelerate its fiber build. Pro-forma for the debt offering, the company maintains its net leverage ratio of 2.5x and has $4B of liquidity, which enables the company to fund the fiber build with cash on hand for approximately the next two years.
MFH

Hot Stocks

18:34 EDT Mercurity Fintech Holding receives listing deficiency notice from Nasdaq - Mercurity Fintech Holding received a deficiency notice from Nasdaq on May 13 that stated the company no longer complies with Nasdaq's listing rules due to its failure to file Form 20-F for the period ended December 31, 2021. Nasdaq informed the company that it has a period of 14 days until May 27 to submit a plan to Nasdaq detailing how the company plans to regain compliance with Nasdaq's continued listing requirements. If Nasdaq accepts the company's Plan to regain compliance in that respect, Nasdaq can grant an exception of up to 180 calendar days from the prescribed Filing due date or until October 28, to regain compliance. The company is currently working on the plan to regain compliance and intends to submit such plan to Nasdaq as soon as practicable prior to May 27.
WHD

Hot Stocks

18:30 EDT Cactus director Semple sells 20,000 class A shares - In a regulatory filing, Cactus director Alan Semple disclosed the sale of 20,000 class A common shares of the company on May 16 at a price of $48.84 per share.
LH

Hot Stocks

18:29 EDT LabCorp launches new skin cancer test - Labcorp "announces new test measures for Lymphocyte-activation gene 3 expression levels by immunohistochemistry in tumor tissue. LAG-3 is an immune-oncology target with demonstrable clinical benefit in patients with melanoma. The test is available for use in both clinical trials and for the care and treatment of patients."
GPI

Hot Stocks

18:28 EDT Group 1 Automotive increases quarterly dividend 2.8% to 37c per share - Group 1 declared a cash dividend of 37c per share for Q1, an increase of 2.8%, or 1c per share, from 4Q21. The dividend will be payable on June 15 to stockholders of record as of June 1.
RIO TRQ

Hot Stocks

18:28 EDT Rio Tinto to amend funding plan with Turquoise Hill Resources - Rio Tinto (RIO) has agreed to amend the previously agreed funding plan with Turquoise Hill Resources (TRQ) in order to provide liquidity of up to $400M in short-term early advances, while the Special Committee of TRQ evaluates Rio Tinto's C$34 per share all-cash proposal to acquire the approximately 49% of the issued and outstanding shares of TRQ that Rio Tinto does not currently own. Subject to the satisfaction of certain minimum liquidity and other conditions, the early advances will be available at any time up to their maturity on 31 December, 2022, and enable TRQ to fund the ongoing development of the Oyu Tolgoi Underground Project in Mongolia. The deadline in the previously agreed funding plan for Turquoise Hill to conduct an initial equity offering of at least $650M has also been extended from the end of August 2022 to the end of 2022.
GPI

Hot Stocks

18:27 EDT Group 1 Automotive increases stock repurchase authorization to $250M - Group 1 Automotive increased its common stock repurchase authorization by $175M to $250M. Year-to-date repurchase activity is 796,060 shares of common stock at an average price of $179.72 for a total of $143.1M, which represents 4.6% of Group 1's outstanding share count at January 1. The company expects that any repurchase of shares will be funded by cash from operations. Repurchased shares will be held in treasury.
ERIC

Hot Stocks

18:23 EDT Ericsson revamps operations, creates new segment reporting structure - Ericsson announced changes to the group structure and Executive Team to position itself to execute on its strategy and growth ambitions while continuing to invest in R&D to maintain its technology leadership. The new Executive Team roles and the new organization will take effect June 1, 2022. To lead in the mobile infrastructure business, a Business Area Cloud Software and Services is created by merging Business Area Digital Services and Business Area Managed Services. This will enable Ericsson to capitalize on the convergence of cloud, software and services. A new Business Area Enterprise Wireless Solutions, comprised of the current Cradlepoint business and Dedicated Networks, is created to take full accountability and focus to develop solutions to meet the growing needs of enterprises and create a dedicated go-to-market organization for enterprise customers including leveraging the established relationship with service providers. The company is also changing its group function structure by adding a Group Function Global Operations. This function will combine the many support functions that are currently spread across the Company, including Sourcing, IT, Digital Transformation, Group Sales, Real Estate and the operations parts of the People and Finance Functions. By creating a global operations function, Ericsson will be able to run its global operations more effectively and consistently across the organization. Following the new group structure, Ericsson will have the following reporting segments: Segment Networks; Segment Cloud Software and Services; Segment Enterprise, and on completion of the acquisition, Vonage will form a separate Business Area included in this segment; Segment Other. The new segment reporting structure will be applied from Q3 2022. Restated financials for new segments for 2020 - 2022 will be published in September 2022 ahead of the Q3 quarterly report. Reference Link
T DISH

Hot Stocks

18:22 EDT Dish enters deal to sell AT&T Internet services - AT&T (T) and DISH (DISH) have entered into a distribution agreement that will allow DISH to offer AT&T Internet services, including AT&T Fiber with Hyper-Gig speeds, to prospective, new and existing DISH customers starting today. Reference Link
BRT

Hot Stocks

18:13 EDT BRT Apartments CEO buys $138K in common stock - In a regulatory filing, BRT Apartments disclosed that its CEO Jeffrey Gould bought 6.9K shares of common stock on May 12th in a total transaction size of $138.4K.
BW

Hot Stocks

18:09 EDT Babcock & Wilcox awarded $68M installation services contract - Babcock & Wilcox Construction Company has been awarded a contract for approximately $68M to provide construction and installation services for a power plant maintenance project in North America.
REVE

Hot Stocks

17:43 EDT REVE Stock trading halted, news pending
FCPT

Hot Stocks

17:40 EDT Four Corners Property Trust acquires NextCare Primary Care property for $1.8M - Four Corners Property Trust announced the acquisition of a NextCare Primary Care property for $1.8M. The property is located in a strong retail corridor in Arizona and is corporate-operated under a net lease with approximately 7 years of term remaining. The transaction was priced at a 6.4% going-in cash capitalization rate, exclusive of transaction costs.
GD

Hot Stocks

17:32 EDT General Dynamics awarded $313.95M Navy contract modification - General Dynamics was awarded a $313.95M cost-plus-fixed-fee modification to a previously awarded contract for additional United Kingdom, or UK, Strategic Weapon Support System kit manufacturing, and submarine industrial base development and expansion, as part of the Integrated Enterprise Plan supporting Columbia-class ballistic missile submarines and the nuclear shipbuilding enterprise. The industrial base development work is for the furtherance of the FY22 National Defense Authorization Act which authorized, and the Department of Defense Appropriations Act, 2022 which appropriated, additional funds for submarine industrial base development and expansion to ensure second- and third-tier contractors are able to meet increased production requirements. Work is expected to be completed by September 2029. This is a joint U.S. / UK program. No funding will be obligated at the time of award. This is a sole source award in accordance with Defense Federal Acquisition Regulation 6.302-1(a)(2)(iii) - only one responsible source and no other supplies or services will satisfy agency requirements. The Naval Sea Systems Command is the contracting activity.
CSCO

Hot Stocks

17:28 EDT Cisco says order cancellations still at low levels - Says has implemented non-cancellation policy on orders.
ENTA

Hot Stocks

17:23 EDT Enanta falls 13% after announcing EDP-938 did not meet primary endpoint
KHC

Hot Stocks

17:21 EDT Kraft Heinz CEO sells $11.5M in common stock - In a regulatory filing, Kraft Heinz disclosed that its CEO Miguel Patricio sold 260K share of common stock on May 16th in a total transaction size of $11.5M.
KSS

Hot Stocks

17:19 EDT Kohl's announces departure of Chief Marketing Officer Greg Revelle - On May 12, Kohl's announced that Greg Revelle, the company's Chief Marketing Officer, will be departing the company effective June 1. On May 18, the company also announced that Doug Howe, the company's Chief Merchandising Officer, is departing the company effective immediately.
SCM

Hot Stocks

17:19 EDT Stellus Capital CEO buys $126K in common stock - In a regulatory filing, Stellus Capital disclosed that its CEO Robert Ladd bought 9.8K shares of common stock on May 16th in a total transaction size of $126.4K.
IO

Hot Stocks

17:15 EDT Ion Geophysical receives delisting notice from NYSE - Ion Geophysical has received a notice from the NYSE that the staff of NYSE Regulation has determined to commence proceedings to delist the common stock of Ion Geophysical from the Exchange because the company had fallen below the NYSE's continued listing standard requiring listed companies to maintain a minimum average global market capitalization over a consecutive 30 trading day period of at least $15M. Trading in the company's common stock was suspended after market close on the NYSE on May 18. The company expects that its common stock will be quoted on the OTC Expert Market.
DEN NTR

Hot Stocks

17:04 EDT Denbury, Nutrien enter agreement for transportation and storage of CO2 - Denbury Carbon Solutions, a wholly owned subsidiary of Denbury (DEN) and PCS Nitrogen Fertilizer, a wholly owned subsidiary of Nutrien (NTR) announced that the parties have reached a term-sheet agreement under which Denbury would transport and store carbon dioxide captured from Nutrien's potential new clean ammonia project at its Geismar, Louisiana location. Nutrien is evaluating its Geismar, Louisiana, ammonia facilities as a potential site for new ammonia production to serve growing demand in agriculture, industrial and emerging energy markets. Nutrien is progressing the proposed project to the front-end engineering design phase, with a final investment decision expected to follow in 2023 and, if approved, full production by 2027. The new plant is expected to have annual production capacity of 1.2M metric tons of clean ammonia, with approximately 1.8M metric tons per year of CO2 to be captured. Under the terms of the agreement, Nutrien would pay Denbury for the transportation and sequestration of the associated CO2 into Denbury's secure underground containment sites. The initial term of the agreement is 12 years, with up to two extension terms of five years each.
PKG

Hot Stocks

17:01 EDT Packaging Corp. raises quarterly dividend by 25% to $1.25 per share - The dividend will be paid to shareholders of record as of June 15, 2022 with a payment date of July 15, 2022.
ADMP

Hot Stocks

17:01 EDT Adamis names David Marguglio president, CEO - Adamis Pharmaceuticals Corporation announced a leadership transition plan to support its efforts to unlock long-term growth and value creation opportunities. David J. Marguglio, Co-Founder and Chief Business Officer, has been appointed President and Chief Executive Officer, effective immediately. Dennis J. Carlo, Ph.D., has retired from the President and Chief Executive Officer roles, and stepped down from the Board of Directors, effective immediately. Marguglio will continue his director role, and a search has commenced to identify a highly qualified and independent director to fill the vacancy resulting from Dr. Carlo's retirement from the Company. Mr. Marguglio commented, "Having led the company to three FDA product approvals, I want to thank Dennis for his many years of service and tireless effort to position Adamis as an innovator in the biopharmaceutical sector. As I step into the CEO role, my goal is to build on the Company's foundation. I believe advancing and broadening our product pipeline through new collaborations and partnerships, combined with growing sales from SYMJEPI and ZIMHI, which was recently launched, will create significant long-term value for patients, providers and stockholders alike."
CSCO

Hot Stocks

17:00 EDT Cisco expects supply problems to continue at same level in Q4 - Says experiencing constraints in 350 critical components. Says China lockdowns made shortages worse than anticipated. Says supply, not demand biggest issue for future earnings. Says still seeing strong demand. Says Q4 guidance not a reflection of demand. Says impossible to catch up on supply in current quarter, even if China reopens. Says customers not showing any shift in behavior. Says product order growth was 8% in Q3. Says orders grew at over 50% for webscale customers in Q3. Comments taken from Q3 earnings conference call.
APP

Hot Stocks

16:47 EDT AppLovin CLO sells $3.39M in common stock - In a regulatory filing, AppLovin disclosed that its Chief Legal Officer Victoria Valenzuela sold 90K shares of common stock on May 16th in a total transaction size of $3.39M.
RKT

Hot Stocks

16:46 EDT Rocket Companies CEO buys $599K in common stock - In a regulatory filing, Rocket Companies disclosed that its CEO Jay Farner bought 69.5K shares of common stock on May 18th in a total transaction size of $599K.
UA UAA

Hot Stocks

16:32 EDT Under Armour CEO Patrik Frisk to step down, Colin Browne named interim CEO - Under Armour announced that Patrik Frisk will step down as President and CEO and as a member of the Board of Directors, effective June 1. The board has initiated a comprehensive internal and external search process to identify a permanent President and CEO. Until a successor is named, the board has appointed Colin Browne, the company's COO, as interim President and CEO, effective June 1. To support the transition, Frisk will remain with Under Armour as an advisor through September 1. Since joining the company in 2016, Browne modernized Under Armour's digital go-to-market strategy and direct-to-consumer model and transformed its supply chain organization, leading to significant margin improvement and operating efficiency. Browne has held the role of COO since 2020 and oversees supply chain, global planning, sustainability, information technology, enterprise data management, commercial optimization, go-to-market strategy, and distribution capabilities. Browne has been an integral part of the company's successful transformation, and his leadership has been critical to navigating global supply challenges caused by the pandemic.
HBB

Hot Stocks

16:32 EDT Hamilton Beach raises quarterly dividend 5% to 10.5c per share - The Board of Directors of Hamilton Beach Brands Holding Company has approved a 5% increase in the company's regular quarterly cash dividend, raising the quarterly amount from 10c per share to 10.5c per share. The dividend is payable on both the Class A and Class B Common Stock and will be paid June 15, 2022, to stockholders of record at the close of business on June 1, 2022.
UA UAA

Hot Stocks

16:31 EDT Under Armour CEO Patrik Frisk to step down, Colin Browne named interim CEO
MRM

Hot Stocks

16:23 EDT Medirom Healthcare receives noncompliance notification from Nasdaq - Medirom Healthcare announced that as a result of its failure to timely file with the U.S. Securities and Exchange Commission its Annual Report on Form 20-F for the year ended December 31, 2021, it received a notice from Nasdaq stating that the company was not in compliance with the periodic filing requirements for continued listing set forth in Nasdaq Listing Rule 5250. Nasdaq listing rules provide the company with 60 calendar days from the date of the notice to submit a plan to regain compliance. The company intends to file the Form 20-F prior to the expiration of the 60-day period.
OCN

Hot Stocks

16:20 EDT Ocwen appoints Sean O'Neil CFO - Ocwen Financial Corporation announced the appointment of Sean O'Neil as executive VP and CFO, effective June 13. He joins Ocwen from Bayview Asset Management, where he served as the company's CFO since 2015.
CSCO

Hot Stocks

16:18 EDT Cisco sees Q4 adjusted gross margin 64%-65% - Sees Q4 adjusted operating margin 31.5%-33.5%.
CSCO

Hot Stocks

16:17 EDT Cisco reports Q3 adjusted gross margin 65.3% - On a non-GAAP basis, total gross margin, product gross margin, and service gross margin were 65.3%, 64.1%, and 68.9%, respectively, as compared with 66.0%, 64.9%, and 68.7%, respectively, in the third quarter of fiscal 2021. Total gross margins by geographic segment were: 64.8% for the Americas, 65.9% for EMEA and 66.4% for APJC. On a GAAP basis, total gross margin, product gross margin, and service gross margin were 63.3%, 61.8%, and 67.3%, respectively, as compared with 63.9%, 62.6%, and 67.4%, respectively, in the third quarter of fiscal 2021.
AUR FDX

Hot Stocks

16:17 EDT FedEx and Aurora expand autonomous trucking pilot in TX ahead of schedule - Aurora Innovation (AUR) and FedEx (FDX) "announced the expansion of their pilot program to autonomously move FedEx shipments on an additional commercial lane in Texas. Aurora is now autonomously hauling freight for FedEx on two commercial lanes: Dallas to Houston, and Fort Worth to El Paso. In March 2022, Aurora's next-generation autonomous trucks - based on the new Peterbilt 579 - began to transport FedEx shipments between Aurora's new terminals in Fort Worth and El Paso. Aurora is making the 600-mile trip on a weekly basis with safety drivers on board and expects to increase the frequency of trips in the coming months. Aurora continues to move shipments for FedEx between Aurora's South Dallas terminal and its new Houston terminal on a daily basis."
AGIO

Hot Stocks

16:16 EDT Agios Pharmaceuticals chief scientific officer Bruce Car to resign - In a regulatory filing, Agios Pharmaceuticals disclosed that on May 15, Bruce Car, Ph.D. notified the company of his decision to resign as chief scientific officer of the company, effective July 31.
SMR

Hot Stocks

16:16 EDT Nuscale Power signs MoU with Associated Electric Cooperative over SMR deployment - NuScale Power and Associated Electric Cooperative signed a Memorandum of Understanding to evaluate NuScale's VOYGR power plants for potential deployment. This announcement showcases the ever-growing demand for NuScale's small modular reactor technology to supply communities across America with reliable, affordable and clean energy. Headquartered in Springfield, Missouri, Associated is owned by and provides wholesale power to a system of six regional transmission cooperatives and their 51 local distribution cooperatives. This cooperative system delivers electricity to 2.1 million people in Missouri, northeast Oklahoma and southeast Iowa. Comprised primarily of rural business owners, families, and industries, Associated is dedicated to serving its members' unique power needs reliably, affordably and responsibly. "We are thrilled to continue NuScale's incredible momentum by exploring this opportunity with Associated Electric Cooperative," said John Hopkins, President and Chief Executive Officer of NuScale. "NuScale and Associated both hold the same values that drive our respective organization's missions and goals - the desire to bring clean, dependable, innovative power solutions to our customers and build a better energy future for all."
GTLS

Hot Stocks

16:15 EDT Chart Industries closes $4M CSC Cryogenic Service Center acquisition - Chart Industries completed the acquisition of CSC Cryogenic Service Center AB, a Swedish company for approximately $4M. The company said, "CSC brings a strong service footprint in the Nordic Region with many overlapping customers to Chart, allowing us to broaden our service and repair presence geographically. Our strong original equipment ("OE") installed base and continued OE forecasted growth in the Nordic region will benefit from this localized support. Not only does this expand our geographic footprint, it broadens our repair and service capabilities for mobile equipment, in particular trailers, as well as ISO containers, stationary and transportable tanks, pumps, flowmeters and LNG fueling stations. In particular, we have a number of customers looking to us for exclusive full care service and maintenance agreements in this region as well as installation & commissioning capabilities for LNG stations. CSC also brings strong relationships with key customers in the marine industry, and utilizing our global commercial team, we expect to realize synergies from the CSC offering with both companies' marine customers."
ICFI

Hot Stocks

16:14 EDT ICF International awarded multiple climate advisory services contracts in Q1 - ICF was recently awarded multiple new and recompete contracts and contract modifications to provide climate advisory services to a number of public sector and commercial clients. The contracts were awarded in Q1. The recent agreements fall into two main service categories: climate resilience and decarbonization. Clients include various U.S. state and local government agencies, several of the nation's largest utilities and global commercial clients.
GLBS

Hot Stocks

16:14 EDT Globus Maritime to purchase two bulk carriers for $70.3M - Globus Maritime announced that it has signed two contracts for the construction and purchase of two fuel efficient bulk carriers of about 64,000 DWT each. The sister ships will be built at Nantong COSCO KHI Ship Engineering in China with the first one scheduled to be delivered during the third quarter of 2024 and the second one scheduled during the fourth quarter of 2024. The total consideration for the construction of both vessels is approximately $70.3M, which the company intends to finance, like the newbuilding announced on May 10, with a combination of debt and cash on hand, although the company will continue to explore the best options at the relevant financing time.
CSCO

Hot Stocks

16:13 EDT Cisco drops 15% to $41.14 after cutting FY22 guidance
HFFG

Hot Stocks

16:11 EDT HF Foods Group receives additional noncompliance letter from Nasdaq - HF Foods Group announced that the company received a notification letter from the Listing Qualifications Department of Nasdaq stating that the company is not in compliance with Nasdaq Listing Rule 5250, which requires timely filing of all required periodic reports with the Securities and Exchange Commission, or SEC. The Nasdaq notification letter was sent as a result of the company's delay in filing its quarterly report on Form 10-Q for the quarter ended March 31. The Nasdaq notification letter has no immediate effect on the listing or trading of the Company's common stock on the Nasdaq Capital Market. The company filed a Notification of Late Filing on Form 12b-25 on May 11. In the Form 12b-25, the company indicated that the filing of the Form 10-Q would be delayed as a result of an ongoing review of accounting issues relating to the Company's business combination with B&R Global on November 4, 2019, in response to a SEC comment letter.
IO

Hot Stocks

16:09 EDT ION Geophysical trading halted, news pending
HSTM

Hot Stocks

16:06 EDT HealthStream acquires remaining stake in CloudCME for $4.08M - HealthStream "announced the completion of its acquisition of the remaining equity interest of CloudCME, a Nashville-based healthcare technology company with a nationwide customer base. HealthStream originally invested in CloudCME in March 2019 when it purchased approximately 20 percent of the equity interest in the company. With its acquisition today of the remaining equity interest in CloudCME, HealthStream gains a best-in-class SaaS-based application for managing all aspects of continuing education within a healthcare organization. The purchase price paid for the outstanding equity of CloudCME that HealthStream did not previously own was approximately $4.08 million in cash, subject to post-closing working capital adjustment, and $4.08 million in shares of HealthStream's common stock issued through a private placement."
IRT

Hot Stocks

16:05 EDT Independence Realty Trust announces $250M stock buyback, boosts dividend 17% - Independence Realty Trust announced that its Board of Directors authorized a repurchase program of up to $250M of the company's common stock. The Board also approved a quarterly dividend of 14c per share of IRT common stock, which represents a 17% increase in the dividend over the prior quarterly rate of 12c per share. The dividend is payable on July 22, 2022 to shareholders of record at the close of business on July 1, 2022. "Today's announcement underscores the strength of our business model and our balance sheet, while providing us with the flexibility to unlock value for our shareholders," said Scott Schaeffer, Chairman and CEO of IRT. "We will continue to execute a disciplined capital allocation strategy that balances our organic growth initiatives, while optimizing our leverage position over time and enhancing our capital return program."
UFCS

Hot Stocks

16:02 EDT United Fire Group increases quarterly dividend 6.7% to 16c per share - The board of directors of United Fire Group approved a dividend increase of 6.7% over the previous quarterly dividend and declared a common stock quarterly cash dividend of 16c per share. This dividend will be payable June 17 to shareholders of record as of June 3.
ENTA

Hot Stocks

16:02 EDT Enanta says EDP-938 did not meet primary endpoint in RSVP study
ENTA

Hot Stocks

16:01 EDT Enanta reports topline data from RSVP study of EDP-938 - Enanta Pharmaceuticals reported topline results for RSVP, its Phase 2b study evaluating EDP-938, a potent N-protein inhibitor, in otherwise healthy adults with community-acquired RSV. In this low-risk patient population which had mild, self-resolving upper respiratory tract infection, EDP-938 did not meet the primary endpoint of reduction in total symptom score compared to placebo, or the secondary antiviral endpoints. However, a statistically significant difference in the number of subjects achieving undetectable RSV RNA at the end of treatment at Day 5 was observed with EDP-938 compared to placebo. Further, EDP-938 demonstrated a favorable safety profile, consistent with that observed in approximately 500 subjects exposed to date. Enanta continues to evaluate EDP-938 in high-risk populations in ongoing and planned clinical studies, including pediatric patients, adult hematopoietic cell transplant recipients, and a high-risk adult population, all of which have the most significant unmet need. "While RSVP did not meet the study endpoints, we are pleased to observe a statistically significant difference in the number of subjects achieving undetectable RSV RNA at the end of treatment with EDP-938, making this the only study that has demonstrated a statistically significant antiviral effect in an otherwise healthy adult population with community-acquired RSV. The effect on RSV RNA viral load is consistent with EDP-938's mechanism of action of inhibiting viral replication," said Jay R. Luly, President and Chief Executive Officer of Enanta Pharmaceuticals. "Although patients were treated within 48 hours of symptom onset, a key observation in this study was that the viral load and symptoms had already peaked and were declining at the time of the first dose, indicating RSV infection resolves quickly in this otherwise healthy population."
LCAP MSPR

Hot Stocks

15:34 EDT Lionheart Acquisition II shareholders approve combination with MSP Recovery - Lionheart Acquisition Corporation II (LCAP), a publicly traded special purpose acquisition company, announced that shareholders of record as of April 18 approved the previously announced business combination with MSP Recovery, a Medicare, Medicaid, commercial, and secondary payer reimbursement recovery company. Pursuant to the business combination, at the closing, MSP will combine with LCAP and the combined company's name will be MSP Recovery, Inc. Following the closing, the shares of Class A Common Stock of the combined company are anticipated to continue to be traded on Nasdaq under the symbol "MSPR" following the closing. The combined company's public warrants are anticipated to continue to be traded on Nasdaq under the symbol "LCAPW", and the new warrants issued in connection with the previously announced and declared LCAP dividend are anticipated to commence trading on Nasdaq under the symbol "MSPRW" when issued. The business combination is expected to close on May 20, the company stated.
AMZN...

Hot Stocks

15:29 EDT NY AG launches probes into social media companies following Buffalo shooting - New York Attorney General Letitia James announced that her office is launching investigations into social media companies in connection with the terror attack in Buffalo that claimed 10 lives and wounded three individuals. The investigations will look into the social media companies and other online resources that the shooter used to discuss and amplify his intentions and acts to carry out this attack. Specifically, the investigations will focus on those platforms that may have been used to stream, promote, or plan the event, including but not limited to Twitch, which is owned by Amazon (AMZN), 4chan, 8chan, and Discord. "The terror attack in Buffalo has once again revealed the depths and danger of the online forums that spread and promote hate," said Attorney General James. "The fact that an individual can post detailed plans to commit such an act of hate without consequence, and then stream it for the world to see is bone-chilling and unfathomable. As we continue to mourn and honor the lives that were stolen, we are taking serious action to investigate these companies for their roles in this attack. Time and time again, we have seen the real-world devastation that is borne of these dangerous and hateful platforms, and we are doing everything in our power to shine a spotlight on this alarming behavior and take action to ensure it never happens again." Other publicly traded social media companies include Meta (FB), Snap (SNAP), and Twitter (TWTR). Reference Link
SRZN

Hot Stocks

15:15 EDT Surrozen publishes article on SZN-1326 data in IBD - On May 16, Surrozen announced the publication of an article by Surrozen scientists in the journal Cellular and Molecular Gastroenterology and Hepatology. The results seen with one of Surrozen's proprietary Wnt mimetic antibodies highlight the potential for this novel approach to treating inflammatory bowel disease. Multiple molecules were evaluated in an acute Dextran Sodium Sulfate mouse colitis model, including SZN-1326, a Wnt mimetic with specificity to Frizzled 5 and low-density lipoprotein receptor-related protein 6. SZN-1326 demonstrated the most rapid and robust repair of the injured colon epithelium without affecting normal epithelium and without causing hyperplasia. Current management of moderate to severe ulcerative colitis leaves a significant unmet medical need for drugs that can directly repair and regenerate the intestinal epithelium and can quickly induce clinical and histological remission in patients. Histologic remission is now increasingly regarded as an important treatment objective for UC, as the absence of microscopic disease activity predicts a better clinical course. There are currently no approved therapies that directly repair the epithelial barrier. Additionally, treatment options are limited once anti-inflammatory agents have failed. In the intestine, Wnt signaling plays an important role in maintaining integrity of the epithelium as part of tissue homeostasis and during injury repair. Since Wnt signaling in the intestinal mucosa is critical for repairing the intestinal epithelium, modulation of Wnt signaling has the potential to achieve epithelial regeneration, reduction in inflammation, improvement in disease control and histological remission and mucosal healing. Surrozen designed an antibody-based platform that generates potent Wnt mimetics, which specifically target select Fzd receptors and co-receptors. In this paper, the effects of multiple Wnt mimetics were evaluated to identify the desired regenerative effects on injured tissue and absence of hyperplasia in uninjured tissues.
SQ

Hot Stocks

14:13 EDT Square acquires GoParrot digital ordering and marketing platform for restaurants - Square, part of Block, announced that it has acquired GoParrot, a digital ordering and marketing platform for restaurants. "GoParrot enables restaurants to connect more easily and directly with customers through powerful omnichannel software. As a long-time Square partner, GoParrot's products already integrate with Square's ecosystem of solutions. With GoParrot, Square sellers can offer an exceptional customer experience with a customizable white-label app that merchants can design to be unique to their brand. Through the app, buyers can seamlessly place orders while also viewing top selling items and deal popups for enhanced personalization. Restaurants can also increase buyer retention by offering consumers an easy way to track loyalty rewards right from their mobile device," the company stated. GoParrot's solutions are currently available in the U.S., Canada, Australia, and the UK, Square notes. Reference Link
CVBF

Hot Stocks

14:02 EDT CVB Financial chairman Raymond O'Brien announces retirement - CVB Financial Corp. announced that Raymond V. O'Brien III has decided to step aside as Chairman of the Boards of CVBF and CBB, effective following the end of his current term as Chairman at CVBF's and CBB's respective annual meetings on May 18, 2022. Mr. O'Brien will continue to serve as a director of CVBF and CBB, and he was elected as Chair of CBB's Board Credit Committee at CBB's annual organizational meeting immediately following the annual meeting. The company also announced that the Board of Directors has elected current director Hal W. Oswalt as Chairman of the Boards of CVBF and CBB. Oswalt will assume this role immediately.
UAL

Hot Stocks

13:04 EDT United applies to launch nonstop service between Washington, D.C., Cape Town - United Airlines announced it has filed an application with the U.S. Department of Transportation for three weekly nonstop flights between Washington, D.C. and Cape Town, South Africa. If approved, United's flights will become the first nonstop service ever between Washington D.C. and South Africa's legislative capital, Cape Town. The company said, "This long-overdue route will benefit important government-to-government connections and increase communication and commerce with a region that has strong cultural ties to South Africa." United's proposed service would begin Nov. 17, 2022, and operate on 787-9 aircraft.
DKNG

Hot Stocks

13:01 EDT DraftKings announces launch of online sportsbook and online casino in Ontario - DraftKings announced the launch of its online sportsbook and online casino products in Ontario, Canada. "DraftKings will deliver customers in Ontario a best-in-class sports betting experience through its top-rated sportsbook app, as well as more than 130 online casino game variations through DraftKings Casino such as baccarat, blackjack, roulette and slots," the company stated. "DraftKings' entry into Canada with our online sportsbook and online casino products is a significant milestone in our expansion efforts as we reach nearly 40-percent of Canada's total population. We look forward to providing the passionate fanbase in Ontario with the most entertaining and responsible gaming experience possible," added Jason Robins, DraftKings co-founder, chairman and CEO.
CMRE

Hot Stocks

12:52 EDT Costamare terminates six shipbuilding contracts for newbuild vessels - In a regulatory filing yesterday, Costamare indicated that on May 16, the company served a notice of termination for six shipbuilding contracts which it had entered into with a shipyard for the construction of two container vessels of 12,690 TEU each and four container vessels of 15,000 each.
SXTC

Hot Stocks

12:32 EDT China SXT announces 1 for 20 reverse share split - China SXT Pharmaceuticals announced that a 1 for 20 reverse split of its ordinary shares was approved by the Company's board of directors on May 10, 2022 and became effective on May 17, 2022. In connection with the reverse share split, the Company's shareholders will receive one new ordinary share of the Company for every twenty shares they hold. The Company's ordinary shares is expected to begin trading on a split-adjusted basis when the market opens on May 19, 2022. The Company has filed the Amended and Restated Articles and Memorandum of Association in connection with the reverse share split. As of May 16, 2022, there were approximately 40,627,868 of the Company's ordinary shares outstanding. Effecting the 1 for 20 reverse split will reduce that amount to approximately 2,031,400. The reverse split will not change the number of the Company's authorized preferred and ordinary shares, which will remain as unlimited.
SFUN

Hot Stocks

12:25 EDT Fang receives NYSE Regulation notice on commencement of delisting - Fang Holdings announced that it received a notice from the NYSE Regulation staff regarding the commencement of delisting proceedings of the Company's American depositary shares on the basis that the ADSs are not suitable for listing due to the Company's failure to file with the Securities and Exchange Commission its annual report on Form 20-F for the year ended December 31, 2020 and current report on Form 6-K for the half year ended June 30, 2021 by May 17, 2022, which is the maximum time allowed under Section 802.01E of the NYSE's Listed Company Manual. The NYSE suspended the trading in the ADSs on May 18, 2022. The Company has until June 2, 2022 to submit a written request to appeal the NYSE Regulation staff's delisting decision.
AMZN

Hot Stocks

12:12 EDT Amazon hit with pregnancy, disability discrimination complaint in New York - New York Governor Kathy Hochul announced the New York State Division of Human Rights has filed a complaint against Amazon, Inc. alleging the company engages in discrimination against pregnant workers and workers with disabilities by denying them reasonable accommodations. The Division also alleges that Amazon has policies that force pregnant workers and workers with disabilities to take an unpaid leave of absence rather than allowing them to work with a reasonable accommodation. "My administration will hold any employer accountable, regardless of how big or small, if they do not treat their workers with the dignity and respect they deserve," Governor Hochul said. "New York has the strongest worker protections in the nation and was one of the first to have protections for workers who are pregnant and those with disabilities. Working men and women are the backbone of New York and we will continue to take a stand against any injustice they face." Reference Link
TSLA

Hot Stocks

12:11 EDT Musk calls ESG 'outrageous scam' after S&P removes Tesla - After Standard and Poor's removed Tesla from its S&P 500 ESG Index, Elon Musk tweeted, "ESG is an outrageous scam! Shame on @SPGlobal. Exxon is rated top ten best in world for environment, social & governance (ESG) by S&P 500, while Tesla didn't make the list! ESG is a scam. It has been weaponized by phony social justice warriors."
VZ

Hot Stocks

12:03 EDT Verizon to allocate additional $97.9M to local capital spending in Texas - Verizon is responding to Texas' exponential and unexpected population increase by allocating an additional $97.9M to its local capital spending to meet growing demands on the network. From January 2020 to April of this year, more than 200,000 Verizon wireless customers have moved to Texas, and data traffic has spiked. Since January 2020, busy-hour traffic in Dallas increased 81.3%, in Houston 84.5%, in San Antonio 74.6%, and Austin a jaw-dropping 323.2%.
REGI

Hot Stocks

12:02 EDT Renewable Energy enters strategic partnership with CFN, Pacific Pride - Renewable Energy Group has entered into strategic collaboration agreements with CFN and Pacific Pride, two cardlock fueling networks, to provide cleaner fuels through their branded cardlock networks. Partnering REG's portfolio of bio-based diesel with CFN and Pacific Pride's vast network of cardlocks will allow the companies to play a critical role in furthering the utilization of cleaner fuels by fleets across North America, REG said in a statement.
BJ

Hot Stocks

12:00 EDT BJ's Wholesale falls -16.0% - BJ's Wholesale is down -16.0%, or -$10.21 to $53.60.
TGI

Hot Stocks

12:00 EDT Triumph Group falls -19.7% - Triumph Group is down -19.7%, or -$4.32 to $17.56.
TGT

Hot Stocks

12:00 EDT Target falls -23.8% - Target is down -23.8%, or -$51.15 to $164.13.
MX

Hot Stocks

12:00 EDT MagnaChip rises 12.9% - MagnaChip is up 12.9%, or $2.24 to $19.57.
TDCX

Hot Stocks

12:00 EDT TDCX rises 15.6% - TDCX is up 15.6%, or $1.82 to $13.51.
STG

Hot Stocks

12:00 EDT Sunlands Online rises 16.5% - Sunlands Online is up 16.5%, or 65c to $4.59.
TSLA...

Hot Stocks

11:28 EDT Tesla ineligible for S&P 500 ESG Index inclusion, S&P announces - Margaret Dorn, Senior Director, Head of ESG Indices, North America at S&P Dow Jones Indices, stated in a blog post dated May 17: "It is that time of year yet again: the seasons are changing, spring is in the air and the S&P 500 ESG Index has undergone its fourth annual rebalance. Just as it has in years past, the changes of the 2022 rebalance reflect the delicate balancing act of providing for broad-based market exposure but with meaningful and measurable sustainability-focused enhancements... one familiar name may stick out as being absent from that list: Tesla. Tesla was ineligible for index inclusion due to its low S&P DJI ESG Score, which fell in the bottom 25% of its global GICS industry group peers. It joins Berkshire Hathaway, Johnson & Johnson and Meta, which have once again met the index methodology's chopping block... But, how can a company whose self-declared mission is to 'accelerate the world's transition to sustainable energy' not make the cut in an ESG index? First and foremost, the GICS industry group in which Tesla is assessed - Automobiles & Components - experienced an overall increase in its average S&P DJI ESG Score. So, while Tesla's S&P DJI ESG Score has remained fairly stable year-over-year, it was pushed further down the ranks relative to its global industry group peers. A few of the factors contributing to its 2021 S&P DJI ESG Score were a decline in criteria level scores related to Tesla's (lack of) low carbon strategy and codes of business conduct. In addition, a Media and Stakeholder Analysis, a process that seeks to identify a company's current and potential future exposure to risks stemming from its involvement in a controversial incident, identified two separate events centered around claims of racial discrimination and poor working conditions at Tesla's Fremont factory, as well as its handling of the NHTSA investigation after multiple deaths and injuries were linked to its autopilot vehicles. Both of these events had a negative impact on the company's S&P DJI ESG Score at the criteria level, and subsequently its overall score. While Tesla may be playing its part in taking fuel-powered cars off the road, it has fallen behind its peers when examined through a wider ESG lens." Reference Link
TJX

Hot Stocks

11:21 EDT TJX expects to repurchase $2.25B-$2.5B of TJX stock this FY
TJX

Hot Stocks

11:11 EDT TJX: In-store inventories 'where we want them to be'
TJX

Hot Stocks

11:10 EDT TJX views Homegoods as strongly positioned in retail environment
TJX

Hot Stocks

11:05 EDT TJX looks to return to FY20 pretax margin level within three years, says CEO
TJX

Hot Stocks

11:04 EDT TJX's Q1 comp sales were a bit lighter than plans, says CEO - Comments taken from Q1 earnings conference call.
UEEC

Hot Stocks

10:36 EDT United Health Products to meet with FDA on July 6 on HemoStyp PMA application - United Health Products provided an update on its FDA regulatory process. As previously disclosed, on April 20, 2022, UHP delivered to the U.S. Food & Drug Administration a supplemented and e-formatted Premarket Approval response for its HemoStyp hemostatic gauze and, as is customary, requested a meeting with the committee responsible for reviewing its PMA application. UHP has accepted the FDA's offer to meet on July 6, 2022, and anticipates receiving feedback on its latest response in advance of this meeting. The company will continue to engage with members of the review committee to address any remaining requests and to ensure a productive interaction in July. There can be no assurance that the PMA application will be approved.
VRTX ZBH

Hot Stocks

10:33 EDT Vertex Pharmaceuticals appoints Suketu Upadhyay to board of directors - Vertex Pharmaceuticals announced that Suketu Upadhyay has been elected to its board of directors as an independent director. He is currently the Executive Vice President and CFO of Zimmer Biomet.
RCL

Hot Stocks

10:32 EDT Celebrity Cruises announces first-ever NFT - Celebrity Cruises is riding the wave of the future of art with its first foray into non-fungible tokens. In partnership with artist Rubem Robierb, a longstanding featured artist with the cruise line, Celebrity has launched the Peacemakers Sunset NFT collection, complementing Robierb's powerful Peacemakers sculpture featured on its brand new ship, Celebrity Beyond. Each NFT includes two money-can't-buy invitations to the ship's exclusive naming ceremony and sailing in Fort Lauderdale, November 4-6. The new NFT collection consists of an edition of five motion art pieces, one of which is currently on display at the Cube Art Fair in Times Square from May 18 - 22. On June 1, the NFTs will then become available for purchase via the OpenSea platform. Proceeds from the sales will go to the artist.
RPAY

Hot Stocks

10:15 EDT Corvia adds Repay as processing partner - Corvia announced it has added Repay Holdings Corporation. The relationship will provide additional fuel for Corvia's aggressive growth trajectory by enhancing merchant and partner servicing and support in traditional retail and specialty e-commerce business segments.
DUO

Hot Stocks

10:14 EDT Fangdd Network Co-CEO Yi Duan resigns - Fangdd Network Group announced that Mr. Yi Duan has resigned as the Chairman of the of the Board of Directors, Co-CEO a member of the Compensation Committee and a member of the Nominating and Corporate Governance Committee for personal reasons. Mr. Duan will continue to serve as a director of the Company. Mr. Xi Zeng, the Company's director and CEO, has been appointed to serve as the Chairman of the Board of Directors, a member of the Compensation Committee and a member of the Nominating and Corporate Governance Committee. These changes became effective today.
BIG

Hot Stocks

10:00 EDT Big Lots falls -14.9% - Big Lots is down -14.9%, or -$4.89 to $27.97.
TGI

Hot Stocks

10:00 EDT Triumph Group falls -17.5% - Triumph Group is down -17.5%, or -$3.82 to $18.06.
TGT

Hot Stocks

10:00 EDT Target falls -25.9% - Target is down -25.9%, or -$55.78 to $159.50.
TDCX

Hot Stocks

10:00 EDT TDCX rises 9.7% - TDCX is up 9.7%, or $1.13 to $12.82.
TCS

Hot Stocks

10:00 EDT Container Store rises 9.7% - Container Store is up 9.7%, or 70c to $7.91.
MX

Hot Stocks

10:00 EDT MagnaChip rises 14.3% - MagnaChip is up 14.3%, or $2.47 to $19.80.
MX

Hot Stocks

09:53 EDT MagnaChip strength attributed to Korean-language report of takeover bid - Strength in shares of MagnaChip Semiconductor (MX) is being attributed to a Korean-language report published by Maeil Business Newspaper that claims LX Group and private equity firm Carlyle (CG) jointly submitted a letter of intent for an acquisition of the chipmaker. Previously, on April 26, Korea Economic Daily's Jun-ho Cha reported that South Korea's LX Group, a split-off from LG Group, was looking to acquire Magnachip and would be making its interest official by submitting a letter of intent. In early trading, MagnaChip shares are up $2.37, or 14%, to $19.70. Reference Link
VEDU

Hot Stocks

09:51 EDT VEDU Stock trading resumes
AMZN

Hot Stocks

09:49 EDT Amazon announces Fire 7, Fire 7 Kids tablets - Amazon announced the next-generation Fire 7 and Fire 7 Kids tablets, which the company said is "bringing more speed, performance, and value to the company's most affordable tablet." The new Fire 7 and Fire 7 Kids offer double the RAM and 40% longer battery life for hours of entertainment, video calling, and fun for every member of the family, while the compact size makes it an on-the-go companion. The Fire 7 Kids includes a kid-proof protective case, a one-year subscription of Amazon Kids+, and a two-year worry-free guarantee. Both tablets are available to order today and will begin shipping on June 29. Fire 7 starts at only $59.99 and is available today for pre-order at www.amazon.com/fire7. The all-new Fire 7 comes in black, denim, and rose colors, with coordinating covers for $28.99, and will begin shipping June 29. Fire 7 Kids is available for pre-order today starting at $109.99, and for the first time, it offers 16GB or 32GB storage options.
OTRA

Hot Stocks

09:48 EDT OTR Acquisition Corporation (Class A Stock) trading resumes
DOCS

Hot Stocks

09:47 EDT Doximity falls -14.7% - Doximity is down -14.7%, or -$4.97 to $28.80.
TGT

Hot Stocks

09:47 EDT Target falls -23.0% - Target is down -23.0%, or -$49.47 to $165.81.
TGI

Hot Stocks

09:47 EDT Triumph Group falls -26.2% - Triumph Group is down -26.2%, or -$5.73 to $16.15.
TCS

Hot Stocks

09:47 EDT Container Store rises 7.6% - Container Store is up 7.6%, or 55c to $7.76.
TJX

Hot Stocks

09:47 EDT TJX rises 10.4% - TJX is up 10.4%, or $5.84 to $62.03.
MX

Hot Stocks

09:47 EDT MagnaChip rises 12.6% - MagnaChip is up 12.6%, or $2.18 to $19.51.
VEDU

Hot Stocks

09:46 EDT VEDU Stock trading halted, volatility trading pause
OTRA

Hot Stocks

09:43 EDT OTR Acquisition Corporation (Class A Stock) trading halted, volatility trading pause
BRCC

Hot Stocks

09:35 EDT Black Rifle Coffee appoints Chris Clark as CTO - Black Rifle Coffee Company has appointed Chris Clark as its Chief Technology Officer. A twenty-five year technology professional with deep retail experience, most recently as Chief Information Officer of Levi Strauss & Co., Clark expands the BRCC executive team and joins a group of experienced leaders who are executing on BRCC's omnichannel approach to grow and scale the company.
SRNE VCKA

Hot Stocks

09:33 EDT Scilex initiates Phase 2 study to evaluate safety, efficacy of SP-103 - Scilex Holding Company announced dosing of the first subject in a Phase 2, randomized, double-blind, placebo-controlled, parallel group, multicenter study to evaluate the safety and efficacy of SP-103 in subjects with acute LBP. Scilex's current marketed product, ZTlido, has label claims regarding superior adhesion qualities as compared to other products and SP-103 has the same adhesion characteristics. Scilex is developing SP-103 to be a triple-strength, non-aqueous lidocaine topical system for the treatment of acute LBP. Acute LBP can range in intensity from a dull, constant ache to a sudden, sharp sensation that leaves the person incapacitated. It is estimated that approximately 65 million adults in the U.S., or 25% of U.S. adults, suffer from acute back pain with a total potential global market opportunity of approximately $10.0 billion by 2026.
LOW

Hot Stocks

09:32 EDT Lowe's says gross margin pressure will shift into Q2 - Says delay of Spring weather has negatively impacted seasonal categories and DIY sales. Says encouraged by improved sales trends in May. Says increased uncertainty in macro environment. Says has seen higher demand across seasonal categories now that the weather has broke in the North. Says confident will deliver first half results in line with full-year guidance. Says gross margin pressure will shift into Q2. Sees first half gross margin up slightly. Comments taken from Q1 earnings conference call.
DSX

Hot Stocks

09:27 EDT Diana Shipping announces time charter contract for M/V Maia - Diana Shipping announced that, through a separate wholly-owned subsidiary, it has entered into a time charter contract with Hyundai Glovis Co. Ltd., for one of its Kamsarmax dry bulk vessels, the m/v Maia. The gross charter rate is $25,000 per day, minus a 5% commission paid to third parties, for a period until minimum September 20, 2023 up to maximum November 20, 2023. The charter is expected to commence on May 23, 2022. The "Maia" is a 82,193 dwt Kamsarmax dry bulk vessel built in 2009. The employment of "Maia" is anticipated to generate approximately $13.43 million of gross revenue for the minimum scheduled period of the time charter.
VTRU

Hot Stocks

09:24 EDT Vitru receives final approval for business combination with Unicesumar - Vitru announced that the antitrust approval of its proposed business combination with CESUMAR - Centro de Ensino Superior de Maringa Ltda, or "Unicesumar," has become final and definitive. On April 29, 2022 Vitru had announced that its proposed business combination with Unicesumar had received a recommendation of approval of the General Superintendence of CADE. The decision was published in the Official Gazette on May 2, 2022. According to Law No. 12,529/2011, there was an additional 15-day waiting period following publication for CADE's decision to become final. This additional waiting period expired on May 17, 2022, and the decision is now final and definitive. The closing of the business combination is expected to take place on May 20, 2022, following which we will begin to integrate the activities of Unicesumar with those of Vitru. Through the proposed business combination, Vitru - through its wholly-owned subsidiary Vitru Brasil Empreendimentos, Participacoes e Comercio S.A. - will own 100% of the total share capital of Unicesumar.
BCTX INCY

Hot Stocks

09:18 EDT BriaCell adds additional clinical sites for Phase I/IIa study of Bria-IMT - BriaCell Therapeutics announces that it has activated Hoag Memorial Hospital Presbyterian and re-engaged Sylvester Comprehensive Cancer Center, part of UHealth - the University of Miami Health System, as two additional clinical sites for the screening and enrollment of advanced breast cancer patients in the Phase I/IIa combination study of BriaCell's lead candidate, Bria-IMT, with Incyte's checkpoint inhibitor, retifanlimab, and its immunomodulator, epacadostat.
ILMN

Hot Stocks

09:18 EDT Illumina and Allegheny Health collaborate to assess in-house genomic profiling - Illumina and Allegheny Health Network - AHN -, an integrated health system serving the Western Pennsylvania area, announced a collaboration to evaluate the impact of in-house comprehensive genomic profiling - CGP - to enhance patient care. The collaboration will assess the value of in-house testing for both tissue and blood samples, versus sending those samples externally, and whether this approach may benefit cancer patients and the broader healthcare system. The collaboration will also work to identify instances where blood-based testing is most beneficial, depending on cancer stages and types. The initiative is part of AHN Cancer Institute's plan to help improve the cancer care pathway through its newly established AHN Clinical Genomics Laboratory in Pittsburgh. The project commenced in 2022 and is slated for one year, with the potential to expand this clinical research in the future.
FOCS

Hot Stocks

09:12 EDT Samson Wealth Management Group to join Focus partner XML Financial - Focus Financial Partners announced that it has entered into a definitive agreement under which Samson Wealth Management Group, a wealth management practice in Fort Washington, Pennsylvania, will join Rockville, Maryland-based Focus partner firm XML Financial Group. The transaction is expected to close in the third quarter of 2022, subject to customary closing conditions. Mark Samson founded Samson Wealth Management in 2012 to provide comprehensive wealth and investment management services to high net worth individuals and families located across the country. Mark and his team follow a customized, holistic approach to help their clients grow, preserve and enjoy their wealth. Mark has been named to the Forbes Best-In-State Wealth Advisors list each year since its inception in 2018 through 2022. This transaction will expand the infrastructure and support resources for both Samson Wealth Management and XML, positioning the combined firm for future growth opportunities. The addition of Samson Wealth Management will also expand XML's presence within the Mid-Atlantic region. Mark will join XML's leadership team.
CRXT

Hot Stocks

09:11 EDT Clarus Therapeutics announces issuance of patent covering JATENZO - Clarus Therapeutics announced that the United States Patent and Trademark Office has issued a new patent for claims that cover Clarus' oral testosterone replacement product, JATENZO. Patent No. 11,331,325 entitled "Pharmaceutical Delivery Systems for Hydrophobic Drugs and Compositions Comprising Same" covers Clarus' commercialized product, JATENZO. The new patent will expire in January 2027. "This new patent further reinforces our already impressive intellectual property portfolio for JATENZO," said Dr. Robert Dudley, President and Chief Executive Officer of Clarus. "We believe that having eight patents listed in FDA's Orange Book underscores our multi-pronged strategy for success in the marketplace by protecting this important asset."
VRSK

Hot Stocks

09:11 EDT Verisk Analytics debuts Infutor-Jornaya product innovations - Verisk Marketing Solutions announced a preview of product enhancements and innovations enabled by the integration of Infutor and Jornaya. The first wave of innovations to come integrates Infutor's identity resolution services and data attributes into Jornaya's solutions for marketers. To enhance data integrity for insurance and other considered purchase categories, Verisk Marketing Solutions is adding Infutor Identity Verification to Jornaya Guardian. The combination enables lead buyers to verify the validity and quality of the identity data received in a lead form, confirm a consumer is who they say they are and ensure leads meet TCPA guidelines. Additionally, adding Infutor's consumer attributes including demographic characteristics to Jornaya Intelligence helps lead buyers better understand the consumers behind the leads they are buying.
ESEA

Hot Stocks

09:10 EDT Euroseas announces new charter for two teu feeder containerships - Euroseas announced a new charter for two newbuilding fuel efficient 2,800 teu feeder containerships currently under construction. Specifically: M/V GREGOS, a modern eco-design 2,800 teu scheduled to be delivered at the end of the first quarter of 2023, entered into a time charter contract for a period of between a minimum of thirty-six and a maximum of forty months at the option of the charterer, at a gross daily rate of $48,000. The new charter will commence in March 2023, once delivered. M/V TERATAKI, a modern eco-design 2,800 teu scheduled to be delivered at the end of the second quarter of 2023, entered into a time charter contract for a period of between a minimum of thirty-six and a maximum of forty months at the option of the charterer, at a gross daily rate of $48,000. The new charter will commence in June 2023, once delivered. Aristides Pittas, Chairman and CEO of Euroseas commented: "We are very pleased to announce three-year charters for the first two of our fuel efficient 2,800 teu feeder containerships under construction, M/V GREGOS and M/V TERATAKI, at a gross daily rate of $48,000 each. The new charters will commence upon delivery of the vessels in March 2023 and June 2023, respectively. Over the period of the charters, the two vessels are expected to contribute in excess of $85m of EBITDA fully repaying our cost to build them in just about 3 years. After these charters, our charter coverage for 2023 increases to about 76% and for 2024 to almost 55%."
GRVI

Hot Stocks

09:09 EDT Grove issued patent for proprietary ad tracking system - Grove SaaS Ad Tech Division, Interactive Offers issued a patent for a proprietary ad tracking system that provides complete transparency for advertisers and publishers. CEO Allan Marshall says, "We have created a way using redirect links to allow advertisers, exchanges and DSPs to access first party contact through programmatic email ads. Using this method, advertisers have the ability to connect directly with the user through a redirect link, giving them full transparency on the impressions validating the end user. By providing access to this technology through a unique tracking pixel, advertisers have a way of verifying each and every impression count and source data, reducing the risk of fraud."
BRQS

Hot Stocks

09:09 EDT Borqs Technologies wins solar plus energy storage contract in Hawaii - Borqs Technologies announced that its solar plus energy storage systems subsidiary Holu Hou Energy, HHE, has partnered with a State Agency, the Hawaii Green Energy Infrastructure Authority, HGIA, and won a contract to supply solar plus energy storage systems to Kunia Village affordable housing community on the island of Oahu. This is a milestone in the Company's strategy in transforming into the renewable energy industry, specifically serving the Multi-Unit Residential Buildings, MURB, market. Kunia Village includes 135 housing units, a church, an administration building, a former store, and a gymnasium where the residents have the opportunity to reduce their electricity bill by enrolling into usage of the electricity generated by the project under a leasing arrangement set up by HHE and HGIA. Under the arrangement, HHE and HGIA have created a 3rd party lease program leveraging HGIA's Green Energy Market Securitization financing product, whereby the community members can enroll in the energy savings program. Each unit will have solar generation as well as a HoluPower energy storage system. The design and installation will be performed by HHE, an approved contractor for HGIA financed projects.
LCID

Hot Stocks

09:08 EDT Lucid Group provides details for manufacturing facility with Saudi partners - Lucid Group hosted a ceremonial signing event to mark the February 2022 agreements with the Ministry of Investment of Saudi Arabia, the Saudi Industrial Development Fund, Emaar, The Economic City, at King Abdullah Economic City and Gulf International Bank that sets the stage for the construction of AMP-2, a world-class Lucid production factory in Saudi Arabia with a capacity of 155,000 electric vehicles. Lucid's new factory to bring advanced electric vehicle manufacturing to Saudi Arabia for the first time with a local capacity of 155,000 units. New Saudi factory expected to address growing global demand for Lucid electric vehicles by increasing Lucid's global production capacity mid-decade to 500,000 EVs per year. Helps catalyze the transformation of Saudi Arabia's economy through Saudi Vision 2030 and the Saudi Green Initiative. Signing ceremony celebrates agreements estimated to provide financing and incentives to Lucid of up to $3.4 billion in aggregate over the next 15 years. Government of Saudi Arabia reaffirms commitment to purchase up to 100,000 Lucid electric vehicles over a ten-year period.
GDDY

Hot Stocks

09:07 EDT GoDaddy and Inky enter email security partnership - GoDaddy announced its partnership with Inky, a cloud-based communication security platform. This partnership brings Inky's anti-phishing and email assistant offering to customers of GoDaddy's Advanced Email Security solution for Microsoft 365. The new partnership replaces the prior advanced secure email gateway solution with Inky's detection capabilities and dynamic banners for GoDaddy customers.
AVCO

Hot Stocks

09:07 EDT Avalon GloboCare signs MOU with Lu Daopei Hematology Institute - Avalon GloboCare announced that the Company has signed a memorandum of understanding, MOU, with Lu Daopei Hematology Institute, LDHI, to co-develop precision companion diagnostics, CDx, for chimeric antigen receptor-T cell therapies. To further strengthen its CDx development capabilities, Avalon has appointed Dr. Hongxing Liu, M.D., M.S., Executive President of LDHI and a world-renowned expert in precision diagnostics for hematologic malignancies, to its Scientific and Clinical Advisory Board. "It is an honor to form this strategic collaboration with the researchers and clinicians at the prestigious Lu Daopei Hematology Institute to advance the clinical development of potentially breakthrough cellular immunotherapies along with companion diagnostics," said David Jin, M.D., Ph.D., President and Chief Executive Officer of Avalon GloboCare. "LDHI will be an ideal partner that has the expertise and capabilities to conduct laboratory and analytic work on cancer biomarkers and precision medicine, as well as access to the clinical and bio-informatics database of the Lu Daopei Hospital. We are especially pleased to welcome Dr. Hongxing Liu to our Scientific and Clinical Advisory Board. Dr. Liu will become an invaluable part and will support our efforts in the development of innovative companion diagnostics in connection with our ongoing and future clinical programs involving cellular immunotherapies." The agreement between Avalon GloboCare and LDHI is subject to negotiation and execution of definitive documentation acceptable to both parties
AGRI

Hot Stocks

09:06 EDT AgriFORCE Growing Systems completes acquisition of IP from Manna Nutritional - AgriFORCE Growing Systems announced it has completed the previously announced acquisition of the intellectual property of Manna Nutritional Group. The IP encompasses patent-pending technologies to naturally process and convert grain, pulses and root vegetables, resulting in low-starch, low-sugar, high-protein, fiber-rich baking flour products, as well as a wide range of breakfast cereals, juices, natural sweeteners and baking enhancers. The core process is covered under a pending patent application in the U.S. and key international markets. Independent lab testing indicates that MNG's soft white wheat baking flour contains over 30 times the fiber, 3 times the protein, and more than 80% less starch than conventional flour without compromising taste, texture and quality. The Company's initial focus is on wheat, in which the flour has applications for baked goods, breads and snacks. As further announced earlier this year, the Company is on track to pilot test its first branded product in the specialty flour category under the brand un(Think) Foods with businesses and consumers later this year. The un(Think) brand aims to evolve the way people think about their favorite foods and create a new standard for nutrition. The Company has also completed the engineering work for small-scale manufacturing and has begun preparation for planned production in Saskatchewan, Canada, with initial operations expected to commence in second half of 2022.
TACO

Hot Stocks

09:05 EDT Del Taco signs multi-unit deal continuing growth in Southeast region - Del Taco announced its newest multi-unit deal that will add six new locations to the state of Alabama in partnership with franchisee Sam Abusaleem in the Huntsville market. Abusaleem has successfully owned and operated several concepts in the retail, real estate and restaurant industry for more than three decades, showing significant growth with each brand he has worked within. "Sam and his team have exceptional experience when it comes to operating multi-unit concepts, paired with a passion to see the Del Taco brand succeed in a market that has been untapped, until now," said Jeff Little, SVP of Development. "We know they will be an excellent steward of the Del Taco brand and are excited to partner with them to bring fresh Mexican food to Huntsville."
CPTK

Hot Stocks

09:05 EDT Brivo announces partnership with Doyle Security Systems - Brivo, a provider in cloud-based access control and smart building technologies that entered into a definitive merger agreement with Crown PropTech Acquisitions, announced a partnership with Doyle Security Systems, the largest family-owned provider of residential and commercial security, fire and medical monitoring systems in New York State and northwest Pennsylvania. Through the partnership, Doyle will expand its product offering to include Brivo Access, Brivo's signature cloud-based access control product, offering cloud-based access control to its customers.
AJRD

Hot Stocks

09:05 EDT Aerojet Rocketdyne chairman recruits Mark Tucker to serve as CEO candidate - Aerojet Rocketdyne executive chairman Warren Lichtenstein, who collectively with his affiliates and the participants in his solicitation owns approximately 5.5% of the company's outstanding shares, announced that his slate of seven highly qualified director candidates has recruited Mark Tucker to serve as its CEO candidate to replace current CEO Eileen Drake. If elected to the board of directors by Aerojet Rocketdyne's shareholders, the Lichtenstein Slate expects to take the steps necessary to appoint Tucker as CEO and task him with fortifying the management team and overseeing operational and financial improvements. Tucker previously served as the company's COO from 2015 through 2020, which was a period of significant growth and shareholder value creation.
INVE

Hot Stocks

09:04 EDT Identiv collaborates with Wiliot on Battery-Assisted Pixel cold chain solution - Identiv announced its collaboration with Wiliot on the first to market Battery-Assisted Pixel - BAP -. The business card-sized BAP is the first Bluetooth Low Energy - BLE - asset management and cold chain scalable solution on the market. The multi-use Pixel aims to provide traceability, authentication, temperature, and capacitive sensing along with location and time stamp capabilities. BAP tags continuously broadcast secure sensing and ID information that any Bluetooth standard device can read with Wiliot integrated software. Tags can also be placed on food packaging, crates, or other consumer items during transport to ensure the temperature stays within predetermined parameters for safe transit. Wiliot's main offering, Battery-Free IoT Pixels, are postage-stamp-sized, passive, lower-cost tags that communicate securely over BLE and harvest their energy from Bluetooth and RFID frequencies. They are not limited by battery life. The tags attach to any product or packaging to sense a range of physical and environmental data fed into the Wiliot Cloud, where machine learning algorithms translate data into actionable insights for businesses across a range of industries.
SRNE RHHBY

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09:04 EDT Sorrento Therapeutics appoints Tammy Reilly to board of directors - Sorrento Therapeutics announced the appointment of Tammy Reilly, to Sorrento's board of directors. Ms. Reilly is the managing partner of a life sciences advisory company, TRDx LLC, an independent firm that she founded 15 years ago to advise life science companies on life cycle management and business development solutions, which includes advice on mergers and acquisitions and strategic and capital markets transactions. Reilly also served in various roles at Roche Laboratories for over 14 years, including sales and marketing leadership positions and most recently in 2005 as Executive Vice President for Oncology and Dermatology at Roche.
BREZ

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09:04 EDT D-Orbit signs strategic agreement with Astralintu Space Technologies - D-Orbit announced that it has signed an agreement with Astralintu Space Technologies, a leading Ecuadorian space logistics company. Under the terms of the agreement, Astralintu will represent D-Orbit for customers in Latin America and the Caribbean, helping D-Orbit expand its commercial presence in the regions. "Countries across the world are participating in the new space economy. With this agreement with Astralintu Space, we are continuing to expand D-Orbit's global footprint," said Renato Panesi, D-Orbit's Chief Commercial Officer. "We look forward to working closely with Astralintu to capture growth opportunities and support the development of a dynamic space industry in Latin America and the Caribbean." Astralintu is a New Space company with capabilities in CubeSat manufacturing and payload integration, and space mission management based in Quito, Ecuador. The company focuses on providing in-orbit and ground station services to new and existing actors in Latin America and the rest of the world. Their S-band ground station will be integrated within the network of Aurora, D-Orbit's proprietary cloud-based mission control software suite, increasing its future global coverage. This integration was recently highlighted in a joint Workshop between the companies during the 2022 Global Conference on Space for Emerging Countries in Quito, Ecuador. As previously announced on January 27, 2022, D-Orbit has entered into a business combination agreement among Breeze Holdings Acquisition Corp
CGC

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09:03 EDT Canopy Growth announces plans to acquire Jetty Extracts - Canopy Growth and Lemurian "Jetty," a California-based producer of high-quality cannabis extracts and pioneer of clean vape technology, announced that they have entered into definitive agreements providing Canopy Growth, by way of a wholly-owned subsidiary, the right to acquire, upon federal permissibility of THC in the U.S. or earlier at Canopy Growth's election, up to 100% of the outstanding capital stock of Jetty. The Agreements are structured as two separate option agreements whereby Canopy Growth has a call option to acquire up to 100% of the equity interests in Jetty. Under the Agreements, Canopy Growth will make aggregate upfront payments in the amount of approximately $69M payable through a combination of cash and Canopy Growth common shares, a majority of which will be Canopy Growth common shares, in exchange for approximately 75% of the equity interests in Jetty, subject to certain adjustments. Upon exercise of the rights to acquire up to 100% of the equity interests in Jetty covered by the first option agreement, Canopy Growth will make an additional payment pursuant to the terms of the Agreements, also to be satisfied through a combination of cash and Canopy Growth common shares. Until such time as Canopy Sub elects to exercise its rights to acquire Jetty, Canopy Growth and Canopy Sub will have no direct or indirect economic or voting interests in Jetty, Canopy Growth and Canopy Sub will not directly or indirectly control Jetty, and Canopy Growth and Canopy Sub, on the one hand, and Jetty, on the other hand, will continue to operate independently of one another.
TGT

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09:02 EDT Target to raise prices 'surgically,' says CEO
FDBC

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09:01 EDT Fidelity D & D Bancorp authorizes share repurchase program up to 3% of stock - Fidelity D & D Bancorp announced that the Board of Directors has approved a plan to purchase, in open market and privately negotiated transactions, up to 3% of its outstanding common stock.
MDXG

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08:58 EDT Prescience Point urges MiMedx to confirm letters of concern from other holders - Prescience Point Capital Management, a research-focused, catalyst-driven investment firm that beneficially owns approximately 6.7% of the outstanding common stock of MiMedx Group, issued the following statement, in part, : "In recent press releases and letters, MiMedx has misleadingly portrayed Prescience Point as a lone disgruntled shareholder. However, from what we understand, several other large MiMedx shareholders, representing millions of MDXG shares, have sent correspondence to the Company outlining similar concerns to ours. With an important vote coming up at the company's annual meeting of shareholders on June 7, 2022, we believe it is imperative that shareholders know the truth. As such, we call upon the Board and management to publicly confirm that they have received letters of concern from other large shareholders in recent weeks," stated Eiad Asbahi, Founder and Managing Partner of Prescience Point. Prescience Point reiterated its intention to WITHHOLD its votes against two members of MDXG's Board of Directors, Phyllis Gardner and James Bierman, who are up for election at the company's annual meeting, and to vote AGAINST approval of the executive compensation package.
CYTO

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08:52 EDT Altamira Therapeutics to divest, spin off all legacy assets by year-end - Altamira Therapeutics issued a Letter to Shareholders providing highlights of the Company's recent achievements and its 2022 outlook. Company highlights include: Altamira's pivot toward becoming a pure-play RNA therapeutics company; The progress of its RNA business and tech strategy to penetrate the multi-billion total addressable market $50B TAM; The strategy with its RNA AM-401 program to achieve its first clinical proof of concept targeting KRAS driven cancers; The rapid global expansion and commercialization of its drug-free nasal spray Bentrio; Timeline of anticipated readouts of several ongoing Bentrio clinical trials; Upcoming clinical data from its AM-125 nasal spray drug program for vertigo; Upcoming regulatory milestones. "Over the last several months we've made tremendous strides in pivoting our business towards an RNA therapeutics pure play," said Thomas Meyer, Altamira's founder, CEO and Chairman. "We've laid the foundation by developing our proprietary OligoPhore / SemaPhoreTM platforms for extrahepatic RNA delivery and are progressing the preclinical development of our AM-401 for treatment of KRAS-driven cancers. Concurrent with our business transition, we have continued to invest in our non-RNA legacy programs and to drive the toward several important milestones. Our drug-free nasal spray Bentrio continues to expand its global commercialization footprint in over 20 countries while we advance three clinical trials. Based on positive interim clinical data for our AM-125 nasal spray drug for vertigo, we look forward to the upcoming read-out from our Phase 2 clinical trial. We plan to divest or spin off all legacy assets by year-end 2022 to more fully realize their value and become a pure play RNA company."
SFUN

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08:49 EDT SouFun trading halted, news pending
TGT

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08:47 EDT Target still has some inventory to work through, says CEO
XPL...

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08:46 EDT Solitario provides update on Lik, Florida Canyon projects - Solitario Zinc is pleased to update exploration and other associated activities on its Lik and Florida Canyon high-grade zinc projects and joint venture plans for the remainder of 2022. Lik Zinc Project: The Lik project hosts an Indicated Resource of 17.6 million tonnes grading 8.07% zinc, 2.68% lead and 50.1 grams per tonne silver and an additional 2.8 million tonnes of Inferred Resource grading 8.64% zinc, 2.73% lead and 38.9 grams per tonne silver. The project is situated approximately 17 kilometers northwest of Teck's operating Red Dog mine, one of the world's largest, highest grade and lowest cost zinc mines. Solitario and its joint venture partner, Teck American Incorporated, a wholly owned subsidiary of Teck Resources Limited recently approved a jointly funded budget for the 2022 Lik work program that consists of exploration drilling and gravity geophysics. Three core holes totaling 650 meters are planned at Lik during the summer field season to test for resource extensions on the northeast and northwest margins of the currently defined resource footprint, with the third hole on the southern margin. Of note, one of the planned drill holes will also test the potential for stacked mineralization. The Induced Polarization geophysical survey conducted on the Lik property in 2021 suggested that the mineralized horizon hosting the Lik deposit flattens to the west and could be at drillable depths in a valley floor situated approximately three kilometers to the west. The planned gravity geophysical survey will test for gravity anomalies potentially associated with buried zinc mineralization. On May 12, 2022, Teck announced the formation of its Zinc Satellite initiative to surface value from Teck's portfolio of world-class zinc development assets. The Lik Zinc Project is one, among five projects selected for Teck's value creating initiative. View Teck's press release in its entirety here. Teck is currently the world's largest net zinc miner based on zinc production from Red Dog in Alaska and Antamina in Peru. Florida Canyon Zinc Project: The Florida Canyon project hosts an Indicated Resource of 2.4 million tonnes grading 10.62% zinc, 1.33% lead and 15.0 grams per tonne silver and an additional 14.9 million tonnes of Inferred Resource grading 9.63% zinc, 1/26% lead and 11.3 grams per tonne silver. Solitario's joint venture partner, Nexa Resources, is focusing its 2022 work program in three critical areas to advance the project: The first is to finish an access road to several near-by communities that currently have no vehicle access. This effort is part of the joint venture's social commitment to people and communities in the vicinity of the Florida Canyon project area. Several kilometers of new road have been completed, as well as significant upgrading of previously pioneered road. The road is expected to be completed before the end of the year. The second significant 2022 program is completion of a comprehensive metallurgical testing program focusing on sulfide dominant mineralization. Nearly five tonnes of previously drilled mineralized core will be subjected to a variety of tests to better estimate zinc, lead and silver recoveries, as well as the grade and quality of Florida Canyon concentrates that would be deliverable to smelters. Finally, drill hole permitting is well underway to significantly expand the area permitted for drilling activities for 2023 and beyond. The permit application will enlarge the area permitted for drilling by approximately 500 percent. Over 80 new drill hole sites are planned in areas to the south, east and southeast of the Florida Canyon deposit. Multiple drill holes can be completed from each site. These drill sites are located on trend with the Florida Canyon deposit to the south and a parallel trend a couple kilometers to the east. Both of these multi-kilometer trends have undrilled high-grade zinc mineralization at surface comparable to the surface mineralization at Florida Canyon.
SMID

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08:43 EDT Smith-Midland Corp names Reliance Precast as SlenderWall licensee - Smith-Midland Corporation announced, Reliance Precast Limited of Papakura, Auckland, New Zealand,as a new licensed producer of its SlenderWall architectural cladding.
RIBT

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08:43 EDT RiceBran announces capacity expansion at MGI Grain facility - RiceBran Technologies announced the initiation of a significant capacity expansion of the Company's MGI Grain Incorporated facility in East Grand Forks, Minnesota. The expansion is expected to double the capacity of the pearling mill, enabling RiceBran to meet growing demand for North American-sourced, grain-based ingredients and with a minimal capital investment and a limited increase in labor. The project will replace one of the mill's main grain de-hullers with a new de-huller/pearler; more than doubling the plant's production capacity. In addition to the new huller, MGI will support increased throughput and quality with the addition of a color sorter, as well as enhancements to the mill's grain receiving, cleaning and conveyance systems. The project, which is being executed by a trusted contractor and RiceBran's own internal engineering team, is deployed in a manner that minimizes disruption to the mill's daily operations. The investments, which totaled less than half-a-million dollars, are expected to be completed in mid-summer 2022.
TGT

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08:41 EDT Target sees returning to 8% operating margin over time
TGT

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08:38 EDT Target sees profit performance beginning to improve in 2H - Doesn't expect environment to be "anything close to normal" in 2H.
EVOK

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08:38 EDT Evoke Pharma, EVERSANA announces data from survey on GIMOTI - Evoke Pharma and EVERSANA announced positive findings from the first patient-centered survey related to GIMOTI. Following the series of market insights gathered on the perception of GIMOTI by prescribers, a research study was initiated to capture patient responses on their individual gastroparesis experiences and feedback on current treatment options. In April 2022, EVERSANA conducted the patient segment of the GIMOTI Awareness, Trial, Usage Study, a quantitative survey designed to measure patient awareness, trial, and product usage of GIMOTI. Key findings: Roughly 50% of users do not see any symptom improvement from existing oral treatment options; 38% of respondents discontinued their GP medications primarily due to either side effects or lack of symptom improvement; Of those respondents who were aware of GIMOTI prior to the survey, 43% are current users; 100% of current GIMOTI users report seeing at least some symptom improvement; diminished nausea is the most cited symptom improvement. "These data, gathered from patients, are promising and indicative of the robust and significant need for additional therapies for patients with gastroparesis and the potential value that GIMOTI may provide," commented Matt D'Onofrio, MBA, Chief Business Officer of Evoke Pharma. "Since the launch of our Patient and Physician Experience Program, we have accumulated insights that align with our commercial strategy and mission to deliver a treatment alternative to gastroparesis patients that meets their needs and provides them symptomatic relief that is often elusive. Patient empowerment is paramount to our business, and we are motivated, more than ever, to bring GIMOTI front and center for patients."
TGT

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08:37 EDT Target sees FY22 share repurchases lower than FY21
BIMI

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08:36 EDT BIMI International announces appointment of new chairman, independent director - BIMI International Medical announced that on May 12, 2022, the Board of Directors of the Company appointed Fnu Oudom to serve as Chairman of the Board and President of the Company, effective immediately. On May 12, 2022, the Board also elected Ms. Sammi Earn Seok Ang as an independent director of the Company, effective immediately.
CELU

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08:36 EDT Celularity announces $30M private placement - Celularity announced that it has entered into a definitive agreement with a single healthcare-focused institutional investor for the purchase and sale of 4,054,055 shares of its Class A common stock at a purchase price of $7.40 per share and warrants to purchase 4,054,055 shares of its Class A common stock at an exercise price of $8.25 per share in a private placement priced at-the-market under Nasdaq rules, resulting in total gross proceeds of approximately $30.0 million before deducting placement agent commissions and other estimated offering expenses. The warrants will be exercisable immediately after the date of issuance and will expire five years following the initial issuance date. The closing of the offering and sale of the Securities is expected to occur on or about May 20, 2022, subject to the satisfaction of customary closing conditions. A.G.P./Alliance Global Partners is acting as the sole placement agent for the offering.
TGT

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08:35 EDT Target expects to reach high end of $4B-$5B CapEx plan for the year
VERU

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08:34 EDT Veru appoints Batten as EVP, Head of US Infectious Disease Franchise - Veru announced the appointment of Joel Batten as Executive Vice President, EVP, and Head of its U.S. Infectious Disease Franchise effective May 23, 2022. Most recently Batten has been the Head of the Respiratory Syncytial Virus, RSV, Franchise at Sobi North America.
AGE

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08:34 EDT AgeX Therapeutics appoints Joanne Hackett as chairperson - AgeX Therapeutics announced that Joanne Hackett has been appointed chairperson of AgeX's board of directors. Hackett joined the board of directors in December 2021. She will serve in a non-executive capacity as AgeX's chairperson. Greg Bailey, who served as AgeX's Chairperson since 2018, will continue to serve as a member of AgeX's board of directors. Hackett is the head of genomic and precision medicine at Iqvia, a world leader in using data, technology, advanced analytics, and expertise to help customers drive healthcare forward.
GNUS DIS

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08:34 EDT Genius Brands signs 20-year deal with Marvel Studies to license 'Stan Lee' - "Stan Lee Universe," Genius Brands International's (GNUS) "Genius Brands" controlled venture with POW! Entertainment, has signed a 20-year deal to license the name and likeness of Stan Lee to Marvel Studios (DIS) for future feature films and television productions, as well as use in Disney theme parks and experiences worldwide. "We are proud to be the stewards of the incredibly valuable rights to Stan Lee's name, likeness, merchandise, and intellectual property brand," said Andy Heyward, Chairman & CEO of Genius Brands. "And, there is no better place than Marvel and Disney where Stan should be for his movies and theme park experiences. As we enter the centennial year of Stan's birthday, December 28, 2022, we are thrilled to see his memory and legacy will continue to delight fans through this new long-term agreement with Marvel." Under the terms of the deal, Marvel Studios has acquired rights to use Stan Lee's name, voice, likeness and signature in movies and television projects, as well as use images, existing footage and existing audio recordings featuring Stan. Exclusive rights to use Stan Lee's name, voice, likeness and signature in theme parks, water parks, cruise lines and in-park merchandise were included for Disney Parks, Experiences and Products as part of the deal.
TCBP

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08:34 EDT TC Biopharm forms scientific advisroy board for cell therapy development - TC Biopharm announced the formation of a scientific advisory board to advance its gamma-delta T cell therapy, OmnImmune for the treatment of Acute Myeloid Leukemia, or AML. Members of the TC BioPharm Scientific Advisory include: Mark Bonyhadi, who will lead the SAB. He is a senior advisor to Qiming Venture Partners USA and former VP of Research at Juno Therapeautics. Prior to this role at Juno, he was Director of Global Business Development for Cell Therapy at Invitrogen and prior to that, Vice President ofResearch at Xycte Therapies and a Senior Scientist at SyStemix. Uma Lakshmipathy has two decades of experience in cell biology, stem cells and translational research and is currently the Director of R&D in Science and Technology and Head of Patheon Translation Services in Pharma Services Group at Thermo Fisher Scientific. Erin Adams is the Joseph Regenstein Professor of Biochemistry and Molecular Biology at the University of Chicago and an expert in molecular immunology.
CCXI

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08:33 EDT ChemoCentryx announces presentation on role of tunnels in HS - ChemoCentryx announced that a poster will be presented at the Society for Investigative Dermatology 2022 Annual Meeting, to be held May 18-21, 2022 in Portland, Oregon, that highlights unique immunological profiles of the subdermal tunnels in hidradenitis suppurativa, and how these profiles are differentiated with the stage of disease severity. The findings support the Company's plans to advance TAVNEOS into Phase III development for the treatment of patients with Hurley Stage III hidradenitis suppurativa. The poster titled, Spatial Transcriptomic Analysis of HS Skin Lesions Reveals that Tunnels are Immunologically Active and Activity Correlates with Disease Severity, will be presented as part of Poster/Exhibit Hall Session 2 on Friday, May 20 between 4:30 PM- 6:30 PM PT. Hidradenitis suppurativa is a chronic, disabling, inflammatory skin disease characterized by neutrophil-rich inflammatory nodules, abscesses, and tunnels. Complement dysregulation and neutrophil activation have been implicated in the pathogenesis of HS. The complement 5a receptor is highly expressed on neutrophils and is a major driver of the pro-inflammatory functions. Clinical assessment of the severity of HS includes staging using the Hurley system, where Hurley Stage III disease defines severe HS and Hurley Stage II denotes a more moderate disease presentation. At the SID 2022 Annual Meeting, ChemoCentryx will present data that show a marked increase in dermal inflammation in severe Hurley Stage III HS lesions compared to moderate Hurley II lesions. Genes for proinflammatory cytokines, chemokines, neutrophil activation factors, and B cells had higher expression in the severe compared to moderate HS lesions. The spatial gradients of cytokine and chemokine gene expression support the idea that more differentiated tunnels in Hurley III disease are intensely immunologically active, potentially contributing to ongoing active severe disease, rather than merely remnant structures of prior disease. TAVNEOS, a potent and specific inhibitor of human C5aR, was previously evaluated in the Phase II AURORA clinical trial in patients with moderate Hurley Stage II or severe Hurley Stage III HS. The data now presented at the SID meeting support and extend the Company's earlier findings showing increased presence of C5a- and C5aR-bearing cells in Hurley Stage III skin biopsies relative to Hurley II samples, and also provide further mechanistic evidence underpinning TAVNEOS's efficacy in patients with severe HS after 12 weeks of treatment in the AURORA trial. ChemoCentryx plans to meet with the FDA to discuss the Phase III development of TAVNEOS in patients with Hurley Stage III (severe) HS late in the second quarter, with the goal of initiating a Phase III clinical trial in those patients in the second half of 2022.
AREC

Hot Stocks

08:31 EDT American Resources signs offtake, financial partnership with Integrity Coal - American Resources announced that it has signed a carbon offtake agreement along with a non-dilutive financial commitment of $2.5 million with a long-standing customer and premier supplier of metallurgical carbon to the global steel and alloy metal marketplace, Integrity Coal Sales, to start its Carnegie 2 mine. This incremental production will enable the Company to benefit from the current strength in the high vol met carbon market, aligning the risk and return for both Integrity and American Resources. High Vol metallurgical carbon is not burned for energy use. Instead, specific characteristics allow it to be blended with iron to make new steel. This quality of product is in high demand in the current market environment given many of the producers in the U.S. are producing from old mines that are expensive to operate and coming to end-of-life. American Resources is focused on mine plans and operations that are built to be low cost once ramped ranging from 20 to 40+ years while also making them safer and more productive operations. Post initial production ramp Carnegie 2 is anticipating adding $25 to $35 million in additional yearly revenue to the company's top line with attractive margins.
NMTR

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08:29 EDT 9 Meters Biopharma presents preclinical data on larazotide - 9 Meters Biopharma announced that Matthew Bryant, PharmD, Vice President of Medical Affairs at 9 Meters, delivered a poster presentation at the American Thoracic Society International Conference, taking place in San Francisco May 13 - 18, 2022. The presentation highlighted preclinical data investigating the use of larazotide, a tight junction regulator, to reduce lung fibrosis in an animal model of idiopathic pulmonary fibrosis. 9 Meters' is currently studying larazotide in a Phase 3 clinical trial for celiac disease. "IPF can be a truly devastating lung disease that results in lung injury and fibrosis, with no known cause," said Dr. Bryant. "We know that changes to the gut microbiome impacts immunopathology and may have a profound effect on lung diseases, and this crosstalk between the gut and lungs is referred to as the gut-lung axis. We look forward to continuing to learn more about the gut-lung axis in IPF, as our results have demonstrated that larazotide's effects on the gastrointestinal epithelial tight junctions may play an important role in reducing lung fibrosis and addressing symptoms of IPF." In the animal model of IPF, larazotide reduced pulmonary fibrosis as compared to controls and the reduction was found to be greater when larazotide was administered orally than when administered intratracheally. The authors concluded that larazotide's intestinal barrier-reinforcing activity may offer a clinical benefit in the treatment of IPF via the gut-lung axis.
APEN

Hot Stocks

08:27 EDT Apollo Endosurgery to highlight products at DDW 2022 - Apollo Endosurgery announced that Apollo products and procedures that utilize Apollo products will be featured in more than 40 academic posters and videos and over 60 podium presentations and lectures at the upcoming Digestive Disease Week 2022 to be held in San Diego, May 21-24. Highlights include: Full presentation of the MERIT study of the Endoscopic Sleeve Gastroplasty procedure's impact on obesity; 5-year follow-up data for Endoscopic Sleeve Gastroplasty; Endoscopic Sleeve Gastroplasty in Class III Obesity; A systemic review and meta-analysis comparison of ESG and laparoscopic sleeve gastrectomy; Revisional Endoscopic Sleeve Gastroplasty and GLP-1 agonist medications; A multicenter study of the efficacy, feasibility and safety of the X-Tack Endoscopic HeliX Tacking System; Closure of colonic EMR defects using the X-Tack Endoscopic HeliX Tacking System. Included with these presented works will be the full data from the landmark Multi-center ESG Randomized Interventional Trial. ESG is a minimally invasive procedure that uses the OverStitch Endoscopic Suturing System to reduce the volume of a person's stomach. The preliminary MERIT results reported in October at the International Federation for the Surgery of Obesity and Metabolic Disorders revealed that patients who underwent ESG demonstrated an excess body weight loss of 49.2% at 12 months, which was a 45% difference in %EWL compared to patients undergoing moderate intensity lifestyle modification. Presentation of the full MERIT dataset will provide additional information on patient responses to ESG and add to a larger body of evidence of more than 250 publications and abstracts reporting positive outcomes after ESG in over 6,500 patients.
PPBT BMY

Hot Stocks

08:20 EDT Purple Biotech announces initiation of Phase 2 study for CM24 - Purple Biotech (PPBT) announced the initiation of the Phase 2 portion of its ongoing study of CM24, a first-in-class monoclonal antibody with the potential to treat multiple cancers. The Phase 2 is an open-label, multicenter study in subjects with metastatic pancreatic cancer, PDAC, to evaluate the safety and tolerability of CM24 in combination with the PD-1 inhibitor Opdivo and chemotherapy. The primary study endpoint is to evaluate preliminary efficacy in 2nd line PDAC. The phase 2 portion of the study is being conducted as part of Purple Biotech's clinical collaboration with Bristol Myers Squibb (BMY). The companies together made the determination to prioritize PDAC over non-small cell lung cancer based on the positive interim data. Accordingly, this decision will allow an increase in the number of subjects that will be participating, and will accelerate this part of the study, and the updated timeline to complete this trial is within 2023. "We are thrilled at the progress being made to help move this treatment forward in the clinical trial process for the potential benefit of patients with pancreatic cancer," said Gil Efron, President and CFO of Purple Biotech. "We are thankful for our partners at BMS for collaborating with us on this study and their support. Importantly, the decision to prioritize the PDAC study will extend the cash runway of Purple Biotech through the end of 2024," added Efron.
PGR

Hot Stocks

08:20 EDT Progressive renews share repurchase authorization up to 25M shares - The Board renewed the Company's authorization to repurchase up to 25 million of its common shares. This authorization, which does not have an expiration date, replaced the prior authorization, which was terminated.
TGT

Hot Stocks

08:20 EDT Target: Customers shifting spending to experiences from goods
FREY

Hot Stocks

08:19 EDT Freyr Battery signs agreement with Vaasa for lease of 130 hectares of land - Freyr has signed an agreement with the City of Vaasa, Finland, for the temporary lease of 130 hectares of land in the GigaVaasa area. This plot is the future site of Freyr's planned battery cell production plant and part of the company's strategic collaboration with the City of Vaasa to develop industrial scale battery technology and production in the country. In 2021, FREYR signed a non-binding memorandum of understanding ("MoU") with the City of Vaasa, providing FREYR with an exclusive right to a site for a potential battery cell plant with the aim to explore opportunities for joint site-development to accelerate supply of clean batteries in Finland. The temporary land lease agreement of the Vaasa plot is 40 hectares larger than the area FREYR reserved in the initial MoU, to increase the company's efforts to accelerate supply to meet the expected increasing demand for localized and decarbonized battery solutions. The agreement now enables FREYR to begin soil investigation and preparatory work as a prelude to potential construction. The lease is valid from May 1 until December 31, 2023, with the option for a one-year extension.
DMGGF

Hot Stocks

08:18 EDT DMG Blockchain Solutions invests $1M in The INX Digital Company - DMG Blockchain Solutions announces a $1M strategic investment in The INX Digital Company, one of the world's first companies to receive FINRA clearance for trading security tokens, and the first to execute an SEC-registered IPO for a digital security made available to the general public. INX has launched a regulated digital asset trading ecosystem and is pioneering a new tokenized economy. DMG's investment in INX is a strategic initiative to promote institutional adoption of cryptocurrencies and blockchain technologies as well as accelerate the development of its Blockseer Core+ strategy. DMG believes that INX represents a multi-billion dollar opportunity as a front-runner in digital asset trading markets. INX is well-positioned to take significant market share as one of the top regulated trading platforms in the next five years. "DMG views this investment in INX as a furthering of its Core+ strategy to drive transaction revenue streams. Our INX partnership offers DMG the opportunity for Blockseer to add to its development roadmap the ability to offer customers new Blockseer-based products," said Sheldon Bennett, DMG's CEO.
AMTI

Hot Stocks

08:18 EDT Applied Molecular Transport sees cash runway into 2024 - The company expects to record a one-time charge, primarily related to severance, in the second quarter of 2022; strategic prioritization extends estimated cash runway into 2024
AMTI

Hot Stocks

08:18 EDT Applied Molecular Transport reducing workforce by 40% - Reducing workforce by approximately 40%, to 81 full-time employees, and focusing on execution of late-stage clinical trials and related CMC activities
AMTI

Hot Stocks

08:17 EDT Applied Molecular Transport appoints Shawn Cross as president, COO - Aligning senior management to support the late-stage focus of the company: Shawn Cross named president and chief operating officer; Brandon Hants assumes role of chief financial officer; Randy Mrsny, Ph.D., stepping down as chief scientific officer.
GPRE

Hot Stocks

08:17 EDT Green Plains announces aquafeed partnership with Riverence Group - Green Plains announced a partnership with the Riverence Group to form a joint venture to expand aquafeed production in Idaho. The venture will produce trout and salmon feeds for the Riverence Group, utilizing wholesome, sustainable ingredients including the 60%+ fermented protein product recently announced after the success of the development trial at Green Plains Wood River. "This partnership is yet another validation of our transformational path, creating a portfolio of innovative ingredients tailored to meet specific customer needs," said Todd Becker, President and Chief Executive Officer of Green Plains. "The Riverence Group is a highly respected aquaculture producer and we are eager to realize the value this collaboration brings to both partners. Using our low-carbon ingredients in Riverence's feeds can help them achieve their goal of using sustainable, domestically produced plant-based ingredients." As part of the joint venture, Green Plains contributed capital and supplied key ingredient services, while the Riverence Group contributed existing assets and a feed offtake agreement to support its own production, helping to meet the rapidly growing consumer demand from aquaculture in North America. The joint venture is anticipated to become operational in 2023.
AMTI

Hot Stocks

08:17 EDT Applied Molecular Transport pauses earlier-stage research programs
AMTI

Hot Stocks

08:16 EDT Applied Molecular Transport evaluating next steps for AMT-126 - Evaluating next steps for AMT-126, which recently demonstrated safety and tolerability in a Phase 1a trial in healthy volunteers
AMTI

Hot Stocks

08:16 EDT Applied Molecular Transport to prioritize advancement of AMT-101 - Preparing for end of Phase 2 meetings with FDA and other regulators to advance AMT-101 to Phase 3 in chronic pouchitis, an orphan indication with no FDA-approved products; Completing the remaining three AMT-101 Phase 2 trials with top-line data readouts in 2022, consistent with previous guidance
XRAY

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08:15 EDT Dentsply Sirona receives notice of filing delinquency from Nasdaq - DENTSPLY SIRONA received written notification from The NASDAQ Stock Market on May 12, 2022 that the Company is no longer in compliance with the Nasdaq Listing Rules since the Company has not yet filed its Quarterly Report on Form 10-Q for the period ended March 31, 2022. Nasdaq Listing Rule 5250(c)(1) requires Nasdaq-listed companies to timely file all periodic reports. This notice from Nasdaq has no immediate effect on the listing of the Company's common stock on the Nasdaq Global Market. As previously reported by the Company in its Notification of Late Filing on Form 12b-25, filed with the Securities and Exchange Commission on May 10, 2022, the Company was unable to file the 10-Q for the period ended March 31, 2022 within the prescribed period because the Company's Audit and Finance Committee, together with independent outside counsel, is conducting an investigation concerning the Company's use of incentives to sell products to distributors in the third and fourth quarters of 2021, whether those incentives were appropriately accounted for and whether the impact of those sales was adequately disclosed in the Company's periodic reports filed with the Commission. The Company expects to file the Quarterly Report as soon as practicable.
AMTI

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08:13 EDT Applied Molecular Transport provides strategy update - Applied Molecular Transport announced strategic actions to focus resources on its lead clinical programs. Strategic Actions Summary: Prioritizing the advancement of AMT-101 into late-stage clinical development, Preparing for end of Phase 2 meetings with FDA and other regulators to advance AMT-101 to Phase 3 in chronic pouchitis, an orphan indication with no FDA-approved products, Completing the remaining three AMT-101 Phase 2 trials with top-line data readouts in 2022, consistent with previous guidance. Evaluating next steps for AMT-126, which recently demonstrated safety and tolerability in a Phase 1a trial in healthy volunteers. Pausing earlier-stage research programs and activities. Aligning senior management to support the late-stage focus of the company: Shawn Cross named president and chief operating officer; Brandon Hants assumes role of chief financial officer; Randy Mrsny, Ph.D., stepping down as chief scientific officer. Reducing workforce by approximately 40%, to 81 full-time employees, and focusing on execution of late-stage clinical trials and related CMC activities. The company expects to record a one-time charge, primarily related to severance, in the second quarter of 2022; strategic prioritization extends estimated cash runway into 2024. "Given the recent positive AMT-101 Phase 2 results in chronic pouchitis, and its broad potential in additional indications, we have taken these strategic actions to prioritize our cash resources to support late-stage clinical advancement, including an anticipated Phase 3 trial in chronic pouchitis, as well as the ongoing Phase 2 trials in UC and RA," said Tahir Mahmood, Ph.D., chief executive officer and co-founder of AMT. "We also continue to explore partnership opportunities for our earlier stage programs and technology platform." Dr. Mahmood continued, "I also want to acknowledge the foundational contributions of AMT's co-founder Randy Mrsny to the technology platform that underpins our product candidates. It has been my great pleasure and honor to work alongside Randy to build AMT in order to create and advance novel oral biologic therapeutics. Parting with the employees who have brought AMT to such an advanced stage is a difficult decision. We thank our AMT colleagues for their contributions to our progress thus far," concluded Dr. Mahmood.
TGT

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08:12 EDT Target CEO expects cost pressures to persist in coming quarters
AAL MSFT

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08:12 EDT American Airlines to use Microsoft Azure as its preferred cloud platform - American Airlines (AAL) and Microsoft (MSFT) are partnering to use technology to create better, more connected experiences for customers and American Airlines team members, supporting the robust operations of the world's largest airline. As part of the partnership, American will use Microsoft Azure as its preferred cloud platform for its airline applications and key workloads, significantly accelerating its digital transformation and making Microsoft one of the airline's largest technology partners.
AIM

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08:11 EDT AIM ImmunoTech provides update on Ampligen long-COVID program - AIM ImmunoTech provided an update on its ongoing efforts to develop an effective therapeutic for "Long COVID" with its investigational drug, Ampligen. A Phase 3 prospective, double-blind, randomized, placebo-controlled trial of rintatolimod in ME/CFS produced objective improvement in exercise tolerance. An analysis of a subset of patients in that trial with early onset of symptoms showed a statistically significant 51.2% positive response. In an amendment to its ongoing, FDA-authorized AMP-511, AIM enrolled four post-COVID patients with new onset ME/CFS following acute COVID-19. Following at least 12 weeks of Ampligen treatment, each of these four patients indicated they had experienced a reduction in fatigue, as measured via Patient-Reported Outcomes questionnaires. A statistical analysis of these data indicated that the decrease in fatigue compared to baseline was statistically significant, despite the small number of patients. Based in part on these early positive data, AIM is working toward filing an Investigational New Drug application with the U.S. Food and Drug Administration for a Phase 2 study of Ampligen for the treatment of Post-COVID conditions. The newly planned IND is for 12 weeks of therapy. AIM CEO Thomas Equels stated: "While the recently published positive data in pancreatic cancer, advanced recurrent ovarian cancer and triple-negative breast cancer make Ampligen in oncology a top priority, we remain dedicated in our efforts to develop an effective therapy for ME/CFS and Long COVID. Millions of people have suffered too long from these debilitating conditions, and we are steadfast in our mission to help alleviate their suffering."
ALDX

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08:10 EDT Aldeyra reports post-hoc analysis from TRANQUILITY trial - Aldeyra reported that a post-hoc analysis using computer automated grading of digital photography from the completed Phase 3 TRANQUILITY dry eye chamber trial demonstrated statistical significance in favor of reproxalap over vehicle for the primary endpoint of reduction of ocular redness. As previously announced, the Phase 3 TRANQUILITY trial failed to meet the primary endpoint of ocular redness as assessed by independent central reviewers. When applied to Aldeyra's Phase 2 dry eye chamber trial, which was completed in late 2021, the computer automated grading assessment confirmed the previously announced achievement of the primary endpoint of ocular redness, which, similar to the Phase 3 TRANQUILITY trial, was originally assessed by independent central reviewers. Aldeyra intends to discuss the results of the post-hoc analyses, as well as the algorithm used for the computer automated assessment of ocular redness,1 with the FDA prior to NDA submission. The computer automated grading of redness in the completed Phase 3 TRANQUILITY and Phase 2 clinical trials of reproxalap is based on digital images captured by portable cameras fitted with eye cups to standardize distance, lighting, focus, hue, and contrast. The assessment consisted of automated selection of temporal conjunctiva from images of subjects focusing on nasal targets in the eye cup. Redness intensity was averaged across all pixels in the selected region, and combined with vessel geometry to generate a theoretical maximum score of 255. The average baseline score from the post-hoc analyses of the Phase 3 TRANQUILITY and Phase 2 clinical trials was approximately 18. Per draft FDA guidance, to be considered for regulatory approval in the United States, a product candidate for the treatment of dry eye disease must, with certain exceptions, demonstrate efficacy in an objective sign in at least two clinical trials and efficacy in a subjective symptom in at least two clinical trials. Statistical significance versus vehicle is generally considered sufficient for demonstration of efficacy. For satisfaction of symptom efficacy requirements, Aldeyra intends to submit two previously completed adequate and well-controlled 12-week symptom trials that pre-specified patient-reported ocular dryness score as a primary endpoint, the Phase 3 RENEW-Part 1 and Formulation Phase 2 clinical trials. Pending discussion with the FDA, for satisfaction of the sign efficacy requirements, Aldeyra intends to submit the ocular redness results from the Phase 3 TRANQUILITY and Phase 2 dry eye chamber trials. If the primary endpoint of Schirmer test is achieved in the Phase 3 TRANQUILITY-2 trial, and pending discussion with the FDA, Aldeyra intends to submit Schirmer test results from both TRANQUILITY trials as evidence for achievement of an additional objective sign of dry eye disease. Top-line results from TRANQUILITY-2 are expected in the second quarter of 2022. Pending discussion with the FDA and enrollment of the ongoing 12-month safety trial in dry eye disease patients, NDA submission for dry eye disease is expected to occur mid-2022.
SRZN

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08:10 EDT Surrozen initiates dosing in Phase 1 trial of SZN-1326 - Surrozen announced that the first subject has been dosed in its three-part Phase 1 clinical trial to evaluate SZN-1326 for the potential treatment of moderate to severe ulcerative colitis. The trial initiation is approximately one quarter earlier than previously expected. Surrozen also recently announced the publication of an article by Surrozen scientists in the journal Cellular and Molecular Gastroenterology and Hepatology The results highlight the potential for this novel approach to treating inflammatory bowel disease. The Phase 1, randomized, placebo-controlled, single- and multiple-ascending-dose study will evaluate the safety, pharmacokinetics, and activity of SZN-1326. The first part of the trial will evaluate single doses of SZN-1326 via intravenous injection or infusion, or subcutaneous injection in healthy volunteers, progressing from 25 mg through 1500 mg. The second part will evaluate multiple ascending doses of SZN-1326 for a period of four weeks in healthy volunteers, with each subject assigned to one of three dose level cohorts increasing from 75 mg IV up to 750 mg IV. The primary endpoint of Parts 1 and 2 of the trial are safety and tolerability of SZN-1326 and secondary outcomes include pharmacokinetics as well as prevalence of Anti-Drug Antibodies. "The dosing of the first participant in our clinical study of SZN-1326 marks a significant milestone for Surrozen as we officially transition to a clinical-stage organization," said Craig Parker, President and Chief Executive Officer of Surrozen. "In addition, the trial marks a milestone in the advancement of Wnt signaling research, which plays an essential role in regulating many biological processes. I am proud of our team's advances in creating uniquely engineered antibodies that selectively modulate the Wnt pathway and their strong and timely execution in completing our preclinical package and initiating our clinical development program months earlier than planned. We look forward to continuing to build a broad discovery and clinical pipeline of Wnt antibodies to repair a broad range of tissues and organs damaged by serious disease."
ATCO

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08:09 EDT Seaspan announces order for four 7,700 TEU dual-fuel LNG newbuilds - Seaspan, a wholly-owned subsidiary of Atlas Corp., announced that it has entered into agreements with a major shipyard to construct four ultra-modern 7,700 TEU dual-fuel liquefied natural gas containership newbuilds. The Vessels are anticipated to be delivered in the third and fourth quarters of 2024, and will enter into long-term charters with a leading global liner customer upon completion. The charters include purchase obligations at the conclusion of the charter terms, and will contribute approximately $0.95B of gross contracted cash flow. The Vessels are anticipated to be financed through existing liquidity, cash flow from operations, and additional borrowings. The transaction remains subject to certain closing conditions.
TGT

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08:09 EDT Target still seeing healthy spending by consumers, says CEO Cornell - Seeing stronger sales trends in recent weeks, says CEO Brian Cornell.
IMMP

Hot Stocks

08:08 EDT Immutep appoints oncologists to its CAB - Immutep announced the appointment of four new members to the Company's Clinical Advisory Board, CAB. The CAB serves as a strategic resource to Immutep as the Company continues to advance its pipeline of LAG-3 programs, including combination therapy programs for lead product candidate eftilagimod alpha. The new appointments to Immutep's CAB are:Scott Antonia, M.D., Ph.D., who currently serves as the director of the Duke Cancer Institute Center for Cancer Immunotherapy and is a member of the Thoracic Oncology disease group as Professor of Medical Oncology. Leisha Amens, M.D., Ph.D. is a Professor of Medicine at the UPMC Hillman Cancer Center. Martin Forster, M.D., Ph.D., is an associate professor at University College London and consultant medical oncologist at University College Hospital. Hans Wildiers, M.D., Ph.D., is a staff member at the Department of Medical Oncology at the University Hospital Leuven, Belgium
HPQ

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08:08 EDT HP Inc. reveals new gaming hardware, software - HP Inc. revealed its newest gaming hardware and software created for gamers everywhere with the thermally innovative OMEN 16 Laptop, accessible Victus 15 Laptop, and a variety of powerful updates to OMEN Gaming Hub to enable elevated gaming experiences for all. OMEN 16.1 Gaming Laptop PC expected to be available by this summer via HP.com and at Best Buy for a starting price of $1199.99 on HP.com. See local retailer for pricing. Victus 15.6 Gaming Laptop PC is expected to be available by this summer via HP.com and other retailers for a starting price of $799.99 on HP.com. See local retailer for pricing.
BYRN CAB

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08:07 EDT Byrna Technologies: Bass Pro Shops, Cabela's to carry certain Byrna products - Byrna Technologies (BYRN) announced that Bass Pro Shops and Cabela's (CAB) will begin carrying the Byrna SD Personal Security Device and associated ammunition and accessories at 46 of its locations at the end of May 2022. The initial order, which ships out Friday, May 20th, is a first step to what Byrna hopes will be a broader rollout to all 177 stores in the Bass Pro Shops and Cabela's universe. Byrna product will also be available for Bass Pro and Cabela's customers to purchase online.
CSTM NINOY

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08:07 EDT Constellium, Morf3D enter joint additive manufacturing development program - Constellium (CSTM) is entering into an agreement with Morf3D to provide Aheadd CP1, one of its proprietary additive manufacturing, AM, powder solutions, to Morf3D, a subsidiary of Nikon Corporation (NINOY). "We are very excited to partner with Morf3D, a leading company in additive manufacturing, on the qualification and development of applications using our Aheadd CP1 aluminium powder," said Alireza Arbab, Head of Additive Manufacturing for Constellium. "Constellium recognized a gap in aluminium powder options for Laser Powder Bed Fusion and has developed new powders specifically for this AM process. We are confident that this program will highlight the benefits of Aheadd CP1 and help set new standards for aluminium component production using LPBF."
SMIT

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08:06 EDT Schmitt Industries enters into LOI for Xact assets divestment - Schmitt Industries has entered into a letter of intent to sell all assets related to its Xact business line. This potential transaction is subject to several contingencies, including the negotiation and execution of definitive transaction agreement, the completion of due diligence to the satisfaction of the acquirer and company board approval.
CDK

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08:06 EDT CDK Global announces extension of expiration date of tender offers - CDK Global announced that it is extending the expiration date of each of its previously announced tender offers relating to any and all of its outstanding 4.500% Senior Notes due 2024, the interest rate of which adjusts from time to time and is currently 5.000%, 4.875% Senior Notes due 2027 and 5.250% Senior Notes due 2029 pursuant to its Offer to Purchase and Consent Solicitation Statement dated April 20, 2022. In conjunction with the Tender Offers, CDK solicited from holders of the Notes consents to the adoption of proposed amendments to the indentures governing the Notes to, among other things, eliminate any obligation to make a Change of Control Offer, substantially all of the other restrictive covenants and certain events of default and other provisions. The Expiration Date for each Tender Offer and Solicitation has been extended from 12:00 midnight, New York City time, at the end of the day on May 20, 2022 to 12:00 midnight, New York City time, at the end of the day on May 27, 2022. As of 5:00 p.m. New York City time, on May 17, 2022, holders of approximately 82.5%, 81.3% and 97.9% of the outstanding aggregate principal amount of the 2024 Notes, 2027 Notes and 2029 Notes, respectively, have validly tendered and not validly withdrawn their Notes. Previously tendered Notes may not be withdrawn. Except for the extension of the Expiration Date as described above, all other terms and conditions of each Tender Offer and Solicitation remain unchanged. Holders that have previously tendered their Notes do not need to re-tender their Notes or take any other action in response to this extension.
CBRE

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08:06 EDT CBRE Group announces $100M investment in Industrious - CBRE Group announced a new $100M investment in Industrious. Earlier this month, Industrious announced its first international acquisitions: The Great Room in Asia and Welkin and Meraki in Continental Europe. CBRE invested approximately $230M in Industrious in late 2020 and early 2021. The new $100M investment is in the form of a convertible preferred-equity security. CBRE continues to be the lead minority investor in Industrious.
TGT

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08:05 EDT Target facing 'multiple' cost pressures, says CEO Brian Cornell
TGT

Hot Stocks

08:05 EDT Target saw 'dramatic' change in sales mix in Q1, says CEO Brian Cornell - Comments taken from Q1 earnings conference call.
BB MGA

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08:05 EDT BlackBerry, Magna collaborate on ADAS solutions - BlackBerry (BB) and Magna International (MGA) have entered into a multi-year agreement to collaborate on various integrated Advanced Driver Assistance Systems solutions. As part of the agreement, BlackBerry will provide Magna with QNX software including the QNX Software Development Platform, QNX OS for Safety, QNX Platform for ADAS, as well as professional engineering services for system-level integration, performance optimization, and solution validation.
JZXN

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08:05 EDT Jiuzi Holdings enters strategic cooperation with Chinese EV brand distributor - Jiuzi Holdings has entered into an one-year strategic cooperation agreement with Anji Chuangxing New Energy Auto Sales, a Chinese car distributor of Anji Changyou, a wholly state-owned electric vehicle maker. The two parties will work together to further the development of the EV industry by, for example, promoting innovative formats of travel and sales of EVs, ensuring safe, reliable and commercially viable application of EVs in long distance transportation, building an EV transportation investment system, and improving the efficiency and quality for travel-related services. Anji Chuangxing's target market is Huzhou city, of the first ecological wellness demonstration cities in China. The collaboration between Zhitongche and Anji Chuangxing will attempt to conduct EV rental services for the first time in Zhejiang Province, specifically targeting the tourism industry.
ICAD

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08:04 EDT iCAD announces new research supporting ProFound AI for DBT - iCAD announced that new research supporting ProFound AI for Digital Breast Tomosynthesis, DBT, will be presented at the Society of Breast Imaging, SBI/ACR, Breast Imaging Symposium, taking place May 16-19 in Savannah, GA. In an oral presentation today at 1:30 pm EDT, Colleen Madden, MD, FACR, Assistant Clinical Professor of Radiology at IUH Ball Memorial Hospital at Indiana University School of Medicine, will present promising findings from a retrospective study titled, "Real-World Breast Cancer Detection Before and After the Implementation of an Artificial Intelligence Detection System in a Digital Breast Tomosynthesis Screening Program." According to study findings, using ProFound AI in clinical practice with DBT, or 3D mammography, significantly enhanced radiologists' screening performance, improved cancer detection rates and reduced the rate of false positives. "This recent investigator initiated study confirms ProFound AI offers invaluable insight that helps radiologists to identify cancers more efficiently and accurately, which could dramatically improve outcomes for patients," said Stacey Stevens, President and CEO of iCAD. "iCAD is the only company to provide a complete portfolio of unrivaled1 AI solutions designed to help radiologists find cancers earlier, while reducing false positives and unnecessary patient recalls, which can cause unnecessary stress for a woman and her family."
PDSB SBBP

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08:04 EDT PDS Biotechnology appoints Sanjay Zaveri to SVP, business development - PDS Biotechnology (PDSB) announced that Sanjay Zaveri has joined PDS Biotech as Senior Vice President, Business Development. As PDS Biotech's Senior Vice President of Business Development, he is responsible for business strategy, and managing the Company's potential licensing and partnering opportunities in support of PDS Biotech's pipeline. Prior to joining PDS Biotech he held the position of Head of Business Development and Corporate Strategy at Strongbridge Biopharma (SBBP). Additionally, PDS Biotech granted Mr. Zaveri nonstatutory stock options to purchase 150,000 shares of PDS's common stock as a material inducement to his employment with PDS Biotech in accordance with Nasdaq Listing Rule 5635(c)(4) and PDS Biotech's 2019 Inducement Plan, as amended. PDS Biotech's 2019 Inducement Plan, as amended, provides for the granting of equity awards to new employees of PDS Biotech. The stock option award has an exercise price of $5.35, the closing price of PDS Biotech's common stock on May 17, 2022. The option award vests over a four-year period, with one-quarter of the shares vesting on the first anniversary of the grant date and then monthly over the following 36 months, subject to continued employment with the company through the applicable vesting dates.
AMTX

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08:03 EDT Aemetis signs six-year agreement with Trillium for renewable natural gas - Aemetis announced today that its Aemetis Biogas Services subsidiary has signed a six-year supply agreement with Trillium to provide an estimated 600,000 MMBtu of renewable natural gas to be used as transportation fuel in California. The RNG replaces up to the equivalent of 4.3 million gallons of diesel fuel, primarily used in heavy duty passenger and cargo vehicles. Aemetis completed Phase 1 of the Central Dairy Digester network in 2020 with two fully operational digesters and four miles of pipeline. The biogas from Phase 1 has been used as process energy at the Aemetis Keyes biorefinery to reduce the facility's dependency on petroleum-based natural gas and to decrease the carbon intensity of fuel ethanol produced. Phase 2 of the network consists of a centralized biogas upgrading facility, a utility gas pipeline interconnection unit, 10 dairy digesters and 32 miles of additional pipeline which are planned to be completed by Q4 2022. Aemetis plans to have more than 60 digesters built and operating by the end of 2026 which are designed to produce approximately 1.6 million MMBtu of RNG per year, displacing approximately 12.5 million gallons of diesel per year. Aemetis has completed construction and is currently commissioning the centralized gas cleanup facility and utility gas interconnect located at the Keyes Ethanol biorefinery where dairy biogas will be upgraded to RNG and injected into the utility pipeline through an interconnection with Pacific Gas and Electric. Upon receiving pathway certification from the California Air Resources Board, the fuel is scheduled to begin deliveries to Trillium in late 2022.
SEEL

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08:03 EDT Seelos Therapeutics receives Notice of Allowance for U.S. patent - Seelos Therapeutics announced it has received a Notice of Allowance for U.S. patent application number 16/833,515 from the United States Patent and Trademark Office covering SLS-007 titled: "Structure-Based Peptide Inhibitors of Alpha-Synuclein Aggregation". This Notice of Allowance covers the method of treating several neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Lewy body dementia and multiple system atrophy, through contacting alpha-synuclein protofilaments with an effective amount of SLS-007. Seelos is currently delivering SLS-007 via an adeno-associated virus in a preclinical study designed to establish the in vivo pharmacokinetic and pharmacodynamic profiles and target engagement. SLS-007 is comprised of endogenously available amino acids and thus is expected to be a novel approach to target prevention of alpha-synuclein aggregation and slow disease progression in synucleinopathy diseases. Preliminary data from the study is expected in the second half of 2022.
LILM

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08:03 EDT Lilium announces 37 new patent applications published by EPO - Lilium announced 37 new patent applications, which have been published by the European Patent Office, EPO. These are engineering inventions for the core technology around the Lilium Jet, spanning several domains: Energy, Propulsion, Structures and Interior, Avionics and Custom Electric, with Lilium focusing more than 70% of its patents on Energy and Propulsion. Daniel Wiegand, Co-Founder and CEO of Lilium said: "We are excited that Lilium is creating and protecting the radical engineering innovations that make the Lilium Jet unique. The applications published today serve as a testament to our engineers' ingenuity and commitment to pushing the limits of technology and reinforcing Lilium's place at the forefront of eVTOL development. These patent filings move us one step closer to commercialization of the Lilium Jet, but they also stand to strengthen innovation in the aviation industry as a whole, with areas like energy needing constant investment in novel and sustainable systems and technologies."
TFFP

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08:01 EDT TFF Pharmaceuticals director buys $538K, CEO buys $76.5K in common stock - In regulatory filings, TFF Pharmaceuticals disclosed that its director Aaron Fletcher bought 109.6K shares in a $538K transaction and its CEO Glenn Mattes bought 16K shares in a $76.5K transaction on May 16th. TFF Pharmaceuticals shares are up 4.9% at $5.35 in pre-market trading.
FRG

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08:00 EDT Franchise Group authorizes $500M stock repurchase program - Franchise Group announced that that its Board of Directors has approved a stock repurchase program under which the Company may repurchase up to $500M of its outstanding shares of common stock over the next three years.
PTOTF

Hot Stocks

07:59 EDT Patriot One selected by Oak View Group for Rupp Arena, Lexington Opera House - Patriot One Technologies announced Central Bank Center has selected the Company's Gateway solution to secure entrances at the Rupp Arena and Lexington Opera House, which are a part of the Central Bank Center located in Lexington, Kentucky. The venues will deploy Patriot One's recently announced SmartGateway solution, and will be implemented in a phased approach, starting with entrances at the Lexington Opera House and the VIP entrances at Rupp Arena, eventually to cover both facilities in their entirety. Both venues are managed by the Oak View Group's OVG360 division, which operates more than 330 entertainment venues across the U.S.
THCA

Hot Stocks

07:50 EDT Surf Air Mobility to become public through Tuscan Holdings Corp. II combination - Surf Air Mobility and Tuscan Holdings Corp. II jointly announced that they have entered into a definitive business combination agreement resulting, subject to the satisfaction or waiver of certain closing conditions, in Surf Air Mobility becoming a publicly listed company. The acquisition of Southern, also announced, and the completion of the business combination with THCA positions SAM to be a leader in the electrification of commercial aviation, providing it with resources necessary to bring electrified powertrain technology to market and expanding and electrifying regional consumer scheduled and charter flight services. Following completion of the transactions, and the successful deployment of SAM's proprietary powertrain technology, SAM plans to deploy the world's largest fleet of hybrid electric aircraft on regional routes being serviced and on additional routes in new markets. SAM intends for its hybrid electric propulsion to reduce operating costs and reduce emissions from regional air travel by offering original equipment manufacturers and third-party operators the ability to upgrade existing aircraft to hybrid electric powertrains. SAM's agreements with AeroTEC and magniX will help the company accelerate the introduction of its proprietary electrification technology. magniX has successfully flown the world's largest fully-electric aircraft to date, a prototype Cessna Grand Caravan 208B, which it calls the eCaravan. SAM is designing its initial hybrid electric Cessna Grand Caravans to have the same flight range capabilities as their fully combustion counterparts, which will allow the company to utilize the hybrid electric Cessna Grand Caravan aircraft across its own existing network, connecting more airports with direct flights and building a regional mass transport platform to sustainably connect communities across the U.S. SAM also intends to make hybrid electric powertrain upgrades available to fleet owners on and off its consumer platform, as well as license its technology to OEMs for new aircraft types. The proposed transaction reflects an implied pro forma equity value of $1.42B, assuming full payment of earnout. The transaction is expected to provide up to $467M in gross cash proceeds to SAM, including committed capital from strategic and financial investors, as well as from THCA's cash in trust. The boards of directors of both SAM and THCA have unanimously approved the proposed business combination, which is expected to be completed in the second half of 2022, subject to, among other things, the approval by THCA's stockholders, satisfaction of the conditions stated in the definitive agreement and other customary closing conditions, including a registration statement being declared effective by the U.S. Securities and Exchange Commission, the receipt of certain regulatory approvals, and the receipt of required approvals to publicly list the securities of the combined company. The mergers are also conditioned on the closing of the acquisition of Southern. Although SAM and Southern are party to the Southern Agreement, there can be no assurance that the closing conditions set forth in the Southern Agreement will be satisfied and the acquisition will be completed.
J

Hot Stocks

07:47 EDT Jacobs awarded 5-year contract renewal with Atlanta Airlines Terminal Company - Jacobs was awarded a five-year contract renewal with Atlanta Airlines Terminal Company - AATC - for facility maintenance services at one of the world's premier aviation facilities, Hartsfield-Jackson Atlanta International Airport. The more than $60M agreement will expand Jacobs' and AATC's relationship. Jacobs will deploy ion(C), a performance data integration and visualization platform that aggregates data from other contractors. Since 2010, Jacobs has performed facility maintenance services, including repair, maintenance and operations of mechanical, electrical, plumbing, ramp repairs and more for 10.3 million square feet of the airport's Central Passenger Terminal Complex.
FPI

Hot Stocks

07:44 EDT Farmland Partners acquires Illinois farm for $2.4M - Farmland Partners announced the closing of the acquisition of a 166-acre Illinois farm for $2.4M. The corn and soybean farm is located in Bureau County and includes a grain bin that can hold 16,000 bushels. FPI now owns 220 farms in the U.S. Corn Belt, spanning 44,700 acres that are leased to 36 tenants.
LSF

Hot Stocks

07:42 EDT Laird Superfood names Anya Hamill interim CFO - Laird Superfood announced the appointment of Anya Hamill as interim CFO effective July 1. Hamill will succeed Valerie Ells who announced her intention to resign, effective June 30 to pursue other opportunities. Hamill possesses more than 20 years of strategic finance experience in public consumer packaged goods and private equity backed emerging companies in the natural food and beverage space. She joined Laird Superfood as VP, financial planning and analysis in April after serving as the CFO of Little Secrets Chocolates since 2018.
AUMN

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07:41 EDT Fabled Silver Gold amends Santa Maria option agreement with Golden Minerals - Fabled Silver Gold wishes to announce that it has amended the payment schedule on May 17, 2022 under its option agreement with Golden Minerals Company with respect to the Santa Maria Project. Pursuant to the terms of the terms of the amended Option Agreement, in order to acquire the Santa Maria Project, Fabled is now required make the final payment of $2,000,000 previously due on December 4, 2022 as follows: Option Payment Timing Payment Amount: December 4, 2022 $1,000,000; March 31, 2023 $250,000; June 30, 2023 $250,000; September 30, 2023 $250,000 December 31, 2023 $250,000. As consideration for the amendment Fabled will, on the date of the first payment mentioned above, issue to GMC that number of common shares of Fabled that are equal to a value of $75,000 at a price per share equal to the closing trading price of the Shares on the TSX Venture Exchange on the trading day immediately prior to the date that such payment is made. The terms of the amendment remain subject to the final approval of the TSXV. Share Issuance to Agora
AYRWF

Hot Stocks

07:39 EDT Ayr Wellness announces first sale from Phoenix cultivation facility - Ayr Wellness announced that it has launched first sales from its Phoenix, Arizona cultivation facility. Concurrently, the Company announced the launch of its national pre-roll brand, STiX Pre-Roll in Arizona. "Sales from our new Arizona cultivation marks a key operational milestone for Ayr, increasing our capacity of high-quality flower in the state," said Jonathan Sandelman, Founder, Chairman and CEO of Ayr. "Having great flower will be crucial to distinguishing our Kynd brand throughout the state, while also allowing us to unveil new offerings like STiX, which represents one of the fastest growing form factors in the market, per BDSA. We've been very impressed with the quality of the flower and yields coming out of the facility, a credit to our cultivation team." The 80,000 sq. ft. cultivation facility began operations in December 2021. The indoor facility has 22 strains under cultivation, with first harvests yielding ~75 g/sq. ft. The Company anticipates increases in yields, THC percentages and terpene percentages in subsequent harvests.
MORF CDAK

Hot Stocks

07:38 EDT Morphic appoints Gibbons as SVP of Regulatory Affiars - Morphic Therapeutic (MORF) announced that Joanne Gibbons has been named Senior Vice President, SVP, of Regulatory Affairs. Gibbons was previously Vice President and Head of Regulatory Affairs at Codiak Biosciences (CDAK).
CVGI

Hot Stocks

07:38 EDT CVG announces amendment to credit facility - CVG announced that on May 12, 2022 it had entered into an amendment to increase its existing senior secured credit facilities to $325 million from $275 million consisting of a $175 million Term Loan A and a $150 million Revolving Credit Facility. The amendment provides the Company with additional capital flexibility to execute upon its transformation and growth initiatives. As part of the amended terms of the agreement, the maturity date of the Senior Secured Credit Facilities has been extended by twelve months to May 12, 2027, the interest rate will decrease by 50 bps at various leverage ratios based on SOFR, and pro-forma leverage will increase from the current 3.25x to 3.75x until December 31, 2022 with a quarterly step down of 25 bps to 3.00x leverage by September 30, 2023 and remain at this level thereafter. Further, separate from the Company's annual $35 million cap, a one-time $45 million capital project basket was included in the amendment. All other key provisions, including the $75 million accordion, acquisition holiday, and other baskets remain unchanged.
MRMD

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07:37 EDT Marimed awarded dispensary license in Ohio - MariMed announced it had been awarded a provisional dispensary license, PDL, by the Ohio Board of Pharmacy. MariMed won this license in the Ohio lottery process. The license allows the Company to develop a medical dispensary in Tiffin, Ohio, located south of Toledo and home to the University of Bucharest and Tiffin University. Under the Ohio regulations, MariMed must complete the buildout and pass final inspection by February of 2023. "We are delighted to enter the medical cannabis program in Ohio," said Bob Fireman, Chief Executive Officer of MariMed. "We intend to seek additional opportunities to expand our cannabis operations in Ohio including the distribution of our award-winning branded products."
ACST

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07:36 EDT Acasti Pharma expects cash to fund GTX-104 through NDA submission - Acasti also reports that it had $43.7M cash on hand as of March 31, 2022, which management continues to expect will fund lead drug candidate GTX-104 through NDA submission, and GTX-102 for ataxia telangiectasia and GTX-101 for postherpetic neuralgia to additional key milestones.
AERC

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07:36 EDT AeroClean provides resources to support government push for cleaner indoor air - AeroClean Technologies offers building owners and operators additional resources in navigating the National COVID-19 Preparedness Plan. The plan, presented by the Biden Administration to assist America in rebounding from the devastating effects wrought by the COVID-19 pandemic, provides a roadmap for fighting the virus with a multi-pronged approach focusing on four key goals, including: Protect Against & Treat COVID-19; Prepare For New Variants; Prevent Economic and Educational Shutdowns; and Continue To Vaccinate The World. The technology in the AeroClean Prgo systems uses hospital-grade HEPA filtration as well as optimized germicidal UV exposure to provide supplemental air cleaning and ventilation that removes and destroys 99.99% of harmful airborne pathogens, so businesses and organizations can meet the federal guidelines as suggested. "We are proud to provide our patented, germicidal UV-C LED technology, expertise, and commitment to helping Americans become more educated on indoor air quality and the resources available to them as they update their existing air filtration and ventilation systems," said Jason DiBona, CEO of AeroClean. "AeroClean Prgo air sanitization is a supplemental, real-time solution that directly answers the federal call to action regarding improving IAQ to help businesses, organizations, and schools better protect their workforce, customers, and students from the harmful effects of airborne pollutants and illness-causing pathogens, including COVID-19."
CYTK

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07:35 EDT Cytokinetics, the ALS Association renew partnership - Cytokinetics and The ALS Association announced the continuation of their partnership in the fight against ALS. Cytokinetics is a sponsor of the 2022 ALS Roundtables, the National Advocacy Conference and the ALS Focus survey program. Cytokinetics is also a Platinum Level Sponsor for initiatives led by The ALS Association Golden West Chapter for people with ALS in the Bay Area. In 2022, Cytokinetics will continue to support and participate in events and initiatives with The ALS Association focused in ongoing disease awareness and education, including the ALS Focus survey program, a patient and caregiver led survey program created to learn about individual experiences with ALS, the National Advocacy Conference and the 2022 ALS Roundtables, events during which patients, caregivers, industry, researchers, insurers and clinicians convene to discuss various topics of importance to the ALS community.
DWAC

Hot Stocks

07:34 EDT Trump Media & Technology Group launches Truth Social Web App - Trump Media & Technology Group announced the launch of the Truth Social Web App, allowing all Americans to access Truth Social from any Internet-connected computer, phone, or device. The launch comes in advance of the originally anticipated May 31 target date.
ALYA

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07:34 EDT Alithya Group signs C$7M in contracts from Splunk partnership - Alithya Group signed three contracts with financial services and public sector customers to provide Splunk platform access and implementation services. The contracts, worth approximately C$7M in the aggregate, will provide Alithya customers with access to Splunk's scalable data collection platform. Splunk technology enables data to be imported and extracted automatically in order to generate comprehensive reports via the platform's dashboard.
ACST

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07:34 EDT Acasti Pharma says PK bridging study of IV GTX-104 met all planned endpoints - Acasti Pharma announced today that the top line results of its pharmacokinetic bridging study with IV GTX-104, the Company's lead drug candidate for the treatment of Subarachnoid Hemorrhage, met all its planned study endpoints. The primary objective of the study was to evaluate the relative bioavailability of IV GTX-104 compared to oral nimodipine in healthy adult male and female subjects, while the secondary objective was to assess its safety and tolerability. The Company plans to submit these results to the US Food and Drug Administration, along with its proposed study design for the Phase 3 safety study which is on track to start in the second half of 2022. The safety study is expected to be the final step required to seek regulatory approval under the 505(b)(2) regulatory pathway before submitting a New Drug Application to the FDA. SAH affects about 50,000 patients per year in the U.S. and represents an estimated total addressable market of more than $300 million in the US alone. There are an estimated additional 55,000 patients in Europe. Based on the improved bioavailability, more convenient and consistent mode of administration, safety and tolerability, management believes GTX-104 has the potential to capture a significant share of the SAH market. The PK study was completed at a single center in Canada and followed a 2-period crossover design where each subject received IV GTX-104 first, followed by oral nimodipine; or oral nimodipine first, followed by IV GTX-104. Fifty-eight subjects were randomized in a ratio of 1:1 between IV GTX-104 first or oral nimodipine first. IV GTX-104 and oral nimodipine was administered to all subjects over a period of 72 hours. A total of 56 and 55 subjects were included in the PK analysis at Day 1 and Day 3, respectively, as two subjects did not complete one of the two periods and one subject was excluded due to a protocol deviation, as prospectively defined in the statistical analysis plan. The primary PK endpoints were maximum concentration during the first 4 hours on Day 1 and the total amount of nimodipine in the blood on Day 3. The secondary endpoint was Cmax measured over 24 hours on Day 3. The ratio of IV/oral is presented below for each endpoint with the corresponding 90% confidence interval. A ratio of 1 indicates no absolute difference between IV GTX-104 and oral nimodipine. The IV/oral rati and its corresponding 90% CI for the primary and secondary endpoints in the subjects who completed each treatment period were as follows: Day 1 Cmax, 0-4hr: 92%; AUC Day 3, 0-24hr: 106%; Day 3 Cmax, 0-24hr: 92%. All three endpoints indicated that statistically there was no difference in exposures between IV GTX-104 and oral nimodipine over the defined time periods for both maximum exposure and total exposure. Plasma concentrations obtained following IV administration showed significantly less variability between subjects as compared to oral administration of capsules, since IV administration is not as sensitive to some of the physiological processes that affect oral administration, such as taking the drug with and without meals, variable GI transit time, variable drug uptake from the GI tract into the systemic circulation, and variable hepatic blood flow and hepatic first pass metabolism. Previous studies have shown these processes significantly affect the oral bioavailability of nimodipine, and therefore cause oral administration to be prone to larger within and between-subject variability. The bioavailability of oral nimodipine capsules observed was only 8% compared to IV GTX-104. Consequently, less than one-tenth the amount of nimodipine is delivered with GTX-104 to achieve the same blood levels as with the oral capsules. In addition, the diurnal variation associated with IV GTX-104 was approximately half of that seen with the oral nimodipine capsules. Diurnal variation takes into consideration variation in body functions over the course of a day. No serious adverse events and no AEs leading to withdrawal were reported during the study. More gastro-intestinal disorders were observed with oral nimodipine, and as expected in the context of a phase I trial conducted in healthy volunteers, more administration and sampling site related events were observed with IV GTX-104. The other most frequently observed AEs were headache, somnolence and hot flashes/flushing.
AVTX

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07:33 EDT Avalo Therapeutics announces first patient dosed in Phase 2 PEAK trial - Avalo Therapeutics announced that the first patient has been dosed in the company's Phase 2 PEAK, A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Safety and Efficacy of AVTX-002 for the Treatment of Poorly Controlled Non-Eosinophilic Asthma K, trial evaluating AVTX-002 for the treatment of non-eosinophilic asthma. "Dosing the first patient in the Phase 2 PEAK trial brings us a step closer to delivering a new treatment option to these patients. Nearly half of all asthma patients have NEA, for which there is no specific treatment currently approved," said Garry A. Neil, MD, President and Chief Executive Officer, Avalo Therapeutics.
DFFN BBIO

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07:32 EDT Diffusion Pharmaceuticals appoints Jaeger as CRO - Diffusion Pharmaceuticals (DFFN) announced that Raven Jaeger, M.S., has joined the Company as its Chief Regulatory Officer, CRO, effective immediately. Jaeger will be responsible for development and implementation of regulatory and related strategies to support the development and commercialization of Diffusion's product development candidates. Jaeger joins Diffusion from BridgeBio Pharma (BBIO) where she was most recently Senior Vice President, Regulatory Affairs.
AVRO

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07:27 EDT Avrobio announces preclinical data from AVR-RD-03 trial - Avrobio announced preclinical data demonstrating the efficacy and safety of AVR-RD-03 gene therapy in a mouse model of infantile onset Pompe disease. The results, which will be presented during the "Disease models and Clinical Applications: Musculo-skeletal Diseases" poster session at the American Society of Gene and Cell Therapy, or ASGCT, annual meeting in Washington, D.C., demonstrate that a gene therapy using hematopoietic stem cells, or HSC, significantly reduced toxic accumulation of glycogen in a mouse model of Pompe disease, including in cardiac and skeletal muscle as well as the central nervous system, or CNS. Eight months post infusion, substrate levels in multiple treated tissues were nearly indistinguishable from normal mice. AVR-RD-03, Avrobio's gene therapy for Pompe disease, includes a proprietary Glycosylation-Independent Lysosomal Targeting-tag which consists of a short peptide sequence linked to the therapeutic protein and is designed to enhance uptake in targeted tissues. Stable engraftment up to eight months after gene therapy, with median vector copy numbers, or VCN, between 1.9 and 3.6 per diploid genome in bone marrow among all study groups. Significant GAA enzyme activity measured in the bone marrow eight months after gene therapy. The supraphysiological GAA enzyme activity levels in bone marrow ranged from a median 300 to 534 nmol/h/mg, compared to +/- 4-6 nmol/h/mg in normal mice. Glucose levels in mice infused with genetically modified HSCs were similar to those of controls. Significant reductions of glycogen observed in key tissues, including: greater than 99% reduction of glycogen in the heart, with reversal of cardiac hypertrophy and normalization of the left ventricular mass index, observed seven months post gene therapy greater than 97% reduction of glycogen in the diaphragm and greater than 85% reduction in the quadriceps. Significant improvements in gait and wire hang functions after gene therapy were also observed seven months post gene therapy Additionally, glycogen was reduced greater than95% in the brain and greater than 99% in the spinal cord, improving locomotor function and demonstrating that modified HSCs crossed the blood-brain barrier where their offspring produced functional protein. Importantly, the data show a typical lentiviral vector preference to integrate into genes, with no indications of proto-oncogene selection or clonal dominance, reinforcing the safety of the vector. Additionally, new data from a separate study show that human HSCs were efficiently transduced, producing robust quantities of transgene product and GAA enzyme activity. Avrobio plans to engage with regulatory agencies on the clinical development strategy for AVR-RD-03 in 2022 and plans to initiate a clinical trial in 2023, subject to regulatory alignment.
PSN

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07:26 EDT Parsons announces Parsons X approach - Parsons unveiled a new, central approach that unifies its digital organization and moves to a new delivery model that reinforces a data-driven focus to delivering digital-enabled solutions: Parsons X. The company said, "Parsons X enhances the company's decades of digital leadership while unlocking an enterprise approach that drives further efficiency, agility, and digital delivery into the critical infrastructure and national security markets. This unifying step for the company's digital offerings is focused on delivering innovative solutions to the world's most pressing challenges and opportunities. Critical infrastructure's digital revolution sparked the need for previously unthought of solutions - like cyber hardening and digital planning - that inevitably lead to the improved safety, security, sustainability, and efficiency of global society...Bringing together innovation from around Parsons, including state-of-the-art cyber solutions, federating data, artificial intelligence and machine learning, and digital twins, Parsons X is a digital accelerator designed to deliver faster, safer, more efficient, and more sustainable infrastructure and national security solutions to customers." While Parsons X extends throughout the enterprise, the inaugural innovation center of excellence will be in the company's PALADIN Lab on the U.S. Army's Aberdeen Proving Ground in Aberdeen, Md.
KSLLF USFD

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07:17 EDT US Foods partners with Kalera to expand fresh produce portfolio - US Foods Holding (SFD) announced a strategic agreement with Kalera (KSLLF). This is US Foods' largest vertical farming relationship to date. The agreement underscores US Foods' commitment to bringing foodservice operators a broad assortment of high-quality produce, year-round. It will also expand the portfolio of local farms that US Foods is sourcing from in various markets in support of its growing Serve Local program. As part of the agreement, Kalera and its wholly owned seed technology business Vindara, will work closely with US Foods to develop and launch new products to US Foods customers in markets across the country. Kalera will bring consistently fresh, sustainable produce year-round to US Foods through its network of controlled environment, indoor farms. The innovative indoor farms use clean room technology, advanced proprietary equipment, and plant and seed science to provide a wide range of high-quality greens such as whole head lettuce, salad mix blends, microgreens, burger leaf toppers, and arugula with less water as compared to traditional field farming.
DTIL GILD

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07:16 EDT Precision BioSciences publishes data from in vivo gene editing program - Precision BioSciences (DTIL) announced preclinical research from its ongoing in vivo gene editing program targeting hepatitis B virus, or HBV, has been published online in Molecular Therapy. Data from this study support the company's continued development of its PBGENE-HBV candidate as a promising gene editing approach that aims to eliminate virus persistence by targeting covalently closed circular DNA, or cccDNA, in patients with chronic hepatitis B. This study was conducted in collaboration with Gilead (GILD) and Acuitas Therapeutics and was also presented this week during the Gene Editing in Cancer and Complex Diseases oral session at the ASGCT Annual Meeting. Precision's gene editing program for chronic hepatitis B is designed to apply ARCUS to knock out persistent cccDNA and inactivate integrated hepatitis B genomes, potentially achieving durable HBsAg loss and functional cure. In this preclinical study, ARCUS efficiently targeted and degraded HBV cccDNA by 85% and reduced expression of HBsAg by 77% in HBV-infected PHH. Importantly, the optimized specificity of the ARCUS nuclease completely prevented detectable chromosomal translocations in the PHH model. To evaluate ARCUS in vivo, novel mouse and non-human primate models were developed that utilized an episomal adeno-associated virus containing a portion of the HBV genome to serve as a surrogate for cccDNA. After administration of LNP containing ARCUS mRNA, high on-target editing and a robust decrease in the cccDNA surrogate was observed in both episomal models, along with a durable 96% reduction of HBsAg in mice. Precision's in vivo development pipeline currently comprises six novel product candidates for genetic diseases. Three of these product candidates are wholly owned -- PBGENE-HBV for chronic hepatitis B, PBGENE-PH1 for primary hyperoxaluria type 1 and PBGENE-PCSK9 for familial hypercholesteremia -- and Precision expects to advance them to IND or CTA over the next three years.
MRNA

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07:15 EDT Moderna, IAVI launch clinical trial of mRNA HIV vaccine antigen in Africa - IAVI and Moderna announced that the first participant screenings are soon to start for a Phase I clinical trial of an mRNA HIV vaccine antigen at the Center for Family Health Research in Kigali, Rwanda, and The Aurum Institute in Tembisa, South Africa. The IAVI-sponsored trial, IAVI G003, builds on progress in HIV vaccine research. Recent findings from the Phase I clinical trial IAVI G001 showed that vaccination with the HIV immunogen eOD-GT8 60mer as a recombinant protein safely induced the targeted immune responses in 97% of recipients. The immune response - targeting and expanding a specific class of B cells - is needed to start the process of developing broadly neutralizing antibodies. The induction of bnAbs is widely considered to be a goal of an efficacious HIV vaccine, and this B-cell activation is the first step in that process. IAVI G003 is designed to test the hypothesis that vaccination with eOD-GT8 60mer, developed by scientific teams at IAVI and Scripps Research, delivered via Moderna's mRNA platform, can induce similar immune responses in African populations as was seen for IAVI G001. IAVI G003 is made possible by the support of the American people through the U.S. President's Emergency Plan for AIDS Relief through the United States Agency for International Development. Additional support is provided by the Bill & Melinda Gates Foundation through grants to Moderna and to the Collaboration for AIDS Vaccine Discovery Vaccine Immunology Statistical Center. Trial sites are expected to enroll a combined total of 18 healthy, HIV-negative adult volunteers for IAVI G003. All participants will receive two doses of eOD-GT8 60mer mRNA, which contains a portion of the viral sequence and cannot cause an infection with HIV. There is no blinding and no randomization in this open-label study; all participants will receive the intervention. Enrolled participants will be monitored for safety for six months after receipt of the last dose, and their immune responses will be examined in molecular detail to evaluate whether the targeted responses will be achieved. The primary trial endpoints are safety and immunogenicity, defined as the ability of a substance to elicit an immune response. Trial endpoint analysis for IAVI G003 will be conducted using immunological assays and completed primarily by scientists at the KAVI-Institute for Clinical Researchin Nairobi, Kenya; the Kenya Medical Research Institute-Centre for Geographic Medicine Research-Coast in Kilifi, Kenya; and in part by scientists at the CAVD-Central Services Facility; IAVI's Neutralizing Antibody Center at Scripps Research, in La Jolla, California; and the VISC.
CABA

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07:12 EDT Cabaletta Bio presents updated interim DesCAARTes trial phase 1 data - Cabaletta Bio presented updated clinical and translational data through 6 months of follow-up in cohorts A1 through A3, safety data through 3 months and persistence data through 1 month of follow-up in cohorts A1 through A4 from the DesCAARTes trial at the American Society of Gene & Cell Therapy, ASGCT, 25th Annual Meeting being held in Washington, D.C. from May 16-19, 2022. Cabaletta's DesCAARTes Phase 1 trial is an open-label, dose escalation, multi-center study of DSG3-CAART in adults with mucosal-dominant pemphigus vulgaris. The trial is designed to determine the maximum tolerated dose of DSG3-CAART in adult subjects with active, anti-DSG3 Ab positive, biopsy confirmed mPV that is inadequately managed by one or more standard therapies. The primary endpoint is incidence of adverse events related to DSG3-CAART within three months of infusion. Secondary endpoints include CAART persistence, anti-DSG3 Ab levels and disease activity. The updated interim DesCAARTes trial Phase 1 data included 12 treated subjects, four cohorts with three patients per cohort; nine having completed six months follow up after DSG3-CAART infusion. The data show: No DLTs, CRS of any grade, or related serious AEs were observed in any subject within three months of DSG3-CAART infusion through cohort A4. There was a dose dependent increase in DSG3-CAART persistence through day 29 in cohorts A1 to A4, indicating that DSG3-CAART cells were not eliminated through immune-mediated rejection. Persistence in cohort A4 approached the lower end of the range that is observed in clinical trials of anti-CD19 CART combined with lymphodepletion in B-cell malignancies. In cohorts A1 to A3: Disease activity was clear or almost clear in 0/9 subjects at screening, 1/9 at pre-infusion, 2/9 at month one, 5/9 at month two, 3/9 at month three, 2/9 at month four, 3/9 at month five and 1/9 at month six after treatment. Through six months post DSG3-CAART infusion, no clear pattern was observed in changes in anti-DSG3 Ab levels or disease activity in the low dose cohorts where the A3 dose represents 6.7 to 10% of the ongoing cohort A5 dose. One subject from cohort A1 was retreated with 500 million cells and persistence in the subject was similar to the three subjects who were originally administered the cohort A3 dose, suggesting that there was not immune-mediated clearance of DSG3-CAART cells after retreatment and repeat dosing of patients is possible, if indicated. Data presented on the company's manufacturing process were as follows: In cohorts A1-A4, the manufacturing success rate was 100% with functional DSG3-CAART cells manufactured successfully from mPV patient apheresis material. Infused DSG3-CAART cells exhibited a stem cell or central memory phenotype with a strong positive correlation between the dose of gene modified T cells and post-infusion persistence to day 29. These data suggest that DSG3-CAART cells are not being eliminated by the pre-existing anti-DSG3 immunity present in mPV.
KKR

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07:12 EDT KKR invests in Alchemer, terms undisclosed - KKR and Alchemer announced that KKR has made a significant majority investment in the company. The investment will support the continued acceleration of Alchemer's growth through marketing, product innovation, industry partnerships and strategic mergers and acquisitions. Financial terms were not disclosed.
ALLG

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07:11 EDT Allego announces high power charging partnership with G&V Energy Group - Allego announced a partnership with G&V Energy Group, a Belgian company, active on the market of fuel stations with a focus on sustainability. G&V manages over 200 fuel stations under different brand names and operates 27 Breakpoint-shops. Allego and G&V Energy Group will enter a long-term high power charging partnership, to install Ultra-Fast Electric Vehicle charging stations at 100 fuel stations soon to become energy hubs throughout Belgium. 12 locations are due to be realized this calendar year, starting with the Noorderlaan in Antwerp. All 12 locations are co-financed by the European Union. Where possible the charging stations will be installed under the existing canopy of the fuel station itself, but as sites expand the installation of Allego canopies is also foreseen. The Electric Vehicle chargers themselves will be kitted in Allego branding for easy recognition for EV drivers. For the longer term with utilization increasing, there is the potential to expand to additional 150 locations. In Belgium, Allego currently operates a network of 5,000 public AC charging points covering more than 305 Flemish municipalities, in addition to 63 DC fast chargers located throughout all of Belgium. At present Allego is rolling out an additional 56 ultra-fast charging locations next to main highways in the coming year 2022-2023, upon completion this will make it the largest DC network in Belgium. In addition to these planned locations, the G&V Allego High power partnership announced today will add another 100 strategic locations in Belgium.
IOBT MRK

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07:10 EDT IO Biotech announces initiation of Phase 3 trial of IOB102-IOB103, KEYTRUDA - IO Biotech (IOBT) announced that it has dosed the first patient in its Phase 3 IOB-013 / KN-D18 trial. The IOB-013 / KN-D18 trial seeks to evaluate IO Biotech's lead candidate, IO102-IO103, in combination with KEYTRUDA, Merck's (MRK) anti-PD-1 therapy, in patients with previously untreated, unresectable or metastatic melanoma. "We are pleased to treat the first melanoma patient, kicking off in Florida and expanding this Phase 3 study with a therapy that has received an FDA Breakthrough Designation across multiple centers in the US, Europe and Australia. This is a strong manifestation of our broad, late-stage development program," said Mai-Britt Zocca, Ph.D., President and CEO IO Biotech. "Executing this clinical trial builds on IO Biotech's recent momentum including financial, international, and organizational expansion." In a Phase 1/2 clinical trial of 30 patients with metastatic melanoma, IO102-IO103, in combination with an anti-PD1 mAb, induced meaningful tumor regression and established durable antitumor response with a manageable tolerability profile for patients. In this study, there was an overall response rate of 80% and a complete response rate of 43%. Grade 3-4 adverse events were seen in 13% of patients. Based on the results from this trial, IO102-IO103, in combination with pembrolizumab, was granted Breakthrough Therapy Designation, BTD, by the U.S. Food and Drug Administration, FDA, for treatment of unresectable/metastatic melanoma.
TIL

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07:09 EDT Instil Bio to present novel TIL analytics at ASGCT - Instil Bio announced results of genomic and correlative analyses in a cohort of patients with metastatic melanoma treated with TILs manufactured by Instil. All TIL products were analyzed using T-cell receptor sequencing, RNA and protein expression, and correlated with patient demographic and historical treatment data. Results will be presented at an oral presentation at the American Society of Gene and Cell Therapy 25th Annual Meeting. In the presentation, a correlation between tumor response and clonal expansion of TILs is shown, as well as an inverse correlation between tumor response and specific T cell populations in the product. Expression profiling and transcriptional network analysis points to "master regulator" genes which can be manipulated during TIL manufacturing to enhance TIL activity.
EXTR

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07:09 EDT Extreme Networks announces new $200M share repurchase program - Extreme Networks announced that its board of directors has authorized an increase to our share repurchase authorization to $200M over a three-year period beginning in the company's upcoming fiscal year commencing July 1. The new authorization reflects Extreme's commitment to a capital allocation policy that offsets dilution from equity incentive programs to maintain a neutral share count. Quarter to date, the company has repurchased $20M worth of shares at an average price of $9.74, leaving a remaining $10M authorization from the prior plan. The new authorization replaces the previous one from February 2020.
GHRS

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07:08 EDT GH Research expects cash to fund operations into 2025 - The company said, "Cash was $270.8 million as of March 31, 2022, compared to $276.8 million as of December 31, 2021. We believe that our existing cash will be sufficient for us to fund our operating expenses and capital expenditure requirements into 2025."
PASG

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07:07 EDT Passage Bio presents interim clinical data from Imagine-1 sudy of PBGM01 - Passage Bio announced the presentation of longer-term clinical and biomarker data from Cohort 1 in Imagine-1, a Phase 1/2 study of PBGM01, a gene therapy for GM1 gangliosidosis. David Weinstein, M.D. M.M.Sc., senior vice president, Clinical Development, Passage Bio, will present the data at 8:30 a.m. ET during a late-breaker oral presentation at the American Society of Gene and Cell Therapy 25th Annual Meeting, being held in Washington, D.C. and virtually. Key Highlights from Late-Breaker Presentation at ASGCT Include: Low dose PBGM01 was well-tolerated and had a favorable safety profile with patient 1 data through 13 months and patient 2 data through seven months: No serious adverse events, complications related to ICM administration or evidence of dorsal root ganglion toxicity were observed in either patient. Both patients showed continued improvement across developmental areas on the Vineland-II and Bayley-III scales: Through the 12-month assessments following PBGM01 administration, improvement from baseline was observed and documented across all developmental areas for patient 1, with notable progression in motor and language domains. Improvement across multiple developmental domains was also observed and documented for patient 2, despite this patient having severe developmental delay at baseline and a prior history of regression. Volumetric MRI data showed meaningful growth in brain volume for patient 1, who was 15 months of age at gene transfer: Volumetric MRI showed increases in brain volume at 12 months compared to baseline for patient 1 in multiple brain regions. Patient 2, who had severe developmental delay at baseline and was 31 months of age at gene transfer, showed a slight decline in brain volume from baseline at six months. Longer-term biomarker data for Beta-galactosidase enzyme activity in CSF and serum showed functional transgene expression: CSF beta-galactosidase activity for both patients increased above levels measured in natural history study (NHS) samples following dosing and were sustained at the upper limit of NHS values. Serum beta-galactosidase activity also increased following administration of PBGM01 for both patients, with patient 1 levels above NHS values at 12-months post-treatment and patient 2 levels normalizing to NHS values at 6-months post-treatment. The Imagine-1 study continues to advance. The first patient in Cohort 2, high dose, late infantile, and both patients in Cohort 3, low dose, early infantile, have been dosed. Interim safety and biomarker data from both cohorts are expected in the second half of 2022.
DNA

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07:07 EDT Ginkgo Bioworks and First Serv to co-develop biosecurity solutions in Qatar - Ginkgo Bioworks and First Serv, a Qatari investment holding company, have entered into a non-binding Memorandum of Understanding to develop and implement new biosecurity capabilities in Qatar. The initial goal of the partnership is to establish Doha as a critical node of a global pathogen monitoring network. Ginkgo, through its biosecurity and public health initiative, Concentric by Ginkgo, provides pathogen monitoring capabilities across thousands of sites including schools, airports, and other congregate settings. The network includes partnerships with laboratories, couriers, and healthcare providers. First Serv plans to develop critical infrastructure to detect emerging pathogens.
ACB

Hot Stocks

07:06 EDT Aurora Cannabis receives EU-GMP certification for facility in Germany - Aurora Cannabis announced the company has received EU-GMP certification for its state-of-the-art medical cannabis production facility in Germany. As a leading manufacturer of medical cannabis worldwide, achieving EU-GMP certification of the company's first German manufacturing site marks a significant milestone in the fulfillment of an awarded tender by the German Federal Institute for Drugs and Medical Devices. Aurora is the distinct market leader in the German flower segment and will now leverage receiving the world's highest quality standard to produce and distribute premium medical cannabis in Germany.
ROMJF

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07:06 EDT Rubicon Organics says Delta Facility receives IMC-G.A.P. Certification - Rubicon Organics announced that its' Delta Facility has received its CUMCS Equivalency IMC-G.A.P. certification. Through the IMC-G.A.P. certification process, CU has declared that Rubicon Organics' dried cannabis products are compliant in accordance with the World Health Organization's guidelines on Good Agricultural Practices Medicinal Plants, the European Medicines Agency's, Guideline on GACP for Herbal Medical Products, and the Israeli Medical Cannabis GACP. Obtaining the Certification provides documented evidence that Rubicon Organics has met IMC-G.A.P.'s, WHO's and EMEA's strict standards for quality and consistency in the cultivation, harvest and primary processing of cannabis needed for export of cannabis inputs to certain jurisdictions, including Israel, Europe and Australia, for further processing into finished good via a GMP certified production facility.
TNXP

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07:04 EDT Tonix Pharmaceuticals extends research collaboration with University of Alberta - Tonix Pharmaceuticals Holding announced it has entered into a license agreement and extended a research collaboration with the University of Alberta focused on identifying and testing broad-spectrum antiviral drugs against future variants of SARS-CoV-2 and other emerging viruses. "The research collaboration is focused on the development and testing of Wnt/beta-Catenin signaling pathway inhibitors as broad-spectrum antivirals against SARS-CoV-2 and other emerging viruses," said Professor Tom Hobman. "During the first phase of the sponsored research, we showed that small molecules that inhibit this pathway also decrease replication of SARS-CoV-2 genomic RNA and dramatically reduce infectious viral titers. Drugs in this class seem to work by inducing peroxisome biogenesis, which in turn enhance production of Type I and III IFNs when cells detect viral genetic material. Peroxisomes are key antiviral signaling platforms that are important for IFN induction and antiviral defense. We believe this work has the potential to lead to drugs that limit the spread and disease burden of SARS-CoV-2 and other RNA viruses, which will support the goal of pandemic preparedness."
AXSM

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07:04 EDT Axsome Therapeutics' AXS-05 shows antidepressant efficacy in Phase 2 trial - Axsome Therapeutics announced the publication of the results from the pivotal ASCEND Phase 2 clinical trial of AXS-05 in major depressive disorder - MDD -. AXS-05 is a novel, oral, investigational receptor antagonist with multimodal activity. The article was published in The American Journal of Psychiatry. The ASCEND trial assessed the efficacy and safety of AXS-05 versus the active comparator bupropion in patients with MDD. A total of 80 patients with a diagnosis of moderate to severe MDD were randomized to receive AXS-05 or bupropion for a total of 6 weeks. The primary endpoint was overall treatment effect. In the trial, AXS-05 demonstrated rapid, substantial, and statistically significant improvement in depressive symptoms and induction of remission compared with bupropion. Remission rates were significantly greater with AXS-05 at week 2 and every time point thereafter. Most secondary outcomes favored AXS-05. AXS-05 was generally well tolerated in the trial. The most common adverse events with AXS-05 were dizziness, nausea, dry mouth, decreased appetite, and anxiety. AXS-05 was not associated with psychotomimetic effects, weight gain, or sexual dysfunction.
IMTX

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07:03 EDT Immatics announces first patient treated with IMA203, nivolumab combination - Immatics announced that the first patient has been dosed in the IMA203 and nivolumab combination Phase 1b dose expansion cohort. This cohort will evaluate Immatics' TCR-engineered cell therapy approach ACTengine IMA203 targeting an HLA-A*02-presented peptide derived from PRAME, in combination with Bristol Myers Squibb's PD-1 checkpoint inhibitor nivolumab, in patients with advanced solid tumors. The objectives of the study will be to evaluate the safety, biological activity, and initial anti-tumor activity of the IMA203 and nivolumab combination. The IMA203 and nivolumab combination Phase 1b dose expansion cohort is expected to enroll up to 18 patients with different types of solid tumors across 10 clinical trial sites in Germany and the U.S. Bristol Myers Squibb will provide Immatics, the study sponsor of the combination trial, with nivolumab as part of a clinical supply agreement. Nivolumab has become the standard of care treatment for many solid cancer indications and we believe it fits well into the IMA203 treatment and observation schedule. According to the clinical trial protocol for ACTengine IMA203, nivolumab will be administered at regular intervals following IMA203 treatment. The primary endpoint of this cohort is to assess the safety of the combination. Anti-tumor activity resulting from the drug combination is a secondary endpoint, which will be assessed through imaging and measured according to the standard Response Evaluation Criteria In Solid Tumors. The combination treatment of IMA203 and nivolumab is part of Immatics' strategy to realize the full clinical potential of IMA203 TCR-T targeting PRAME. Based on this strategy, the company has expanded the IMA203 trial to a total of three Phase 1b dose expansion cohorts - each designed to assess observed objective response rates, demonstrate durability of response, and form the basis for enrollment in pivotal studies. In addition to the IMA203 and nivolumab combination, Immatics will also investigate IMA203 as monotherapy and IMA203CD8, a next-generation cell therapy where IMA203-engineered T cells are co-transduced with a CD8alphabeta co-receptor.
F...

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06:59 EDT EU passenger car registrations down 20.6% in April - In April, new passenger car registrations in the European Union saw a significant drop of 20.6% as supply chain issues continued to weigh heavily on car production, according to the European Automobile Manufacturers Association. With the exception of the pandemic year in 2020, this was the weakest April result in terms of volumes sold since records began with 684,506 units sold, the group stated. All major markets contributed to the region's negative performance, with Italy down 33.0%, France down 22.6%, Germany down 21.5% and Spain down 12.1%, the group added. Publicly traded automakers include Daimler AG (DDAIF), Ford (F), General Motors (GM), Honda (HMC), Nissan (NSANY), Stellantis (STLA), Tesla (TSLA), Toyota (TM) and Volkswagen (VWAGY).
ACM

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06:57 EDT Aecom targets science-based net-zero carbon emissions by 2040 - Key pillars of AECOM's sustainable legacies strategy: Achieve net-zero carbon emissions: While developing and implementing best practices and achievable goals for its clients, AECOM has continued to further its own carbon emissions goals with one of the first net zero targets validated by the Science Based Targets initiative. The company has committed to achieving science-based net zero by 2040, which includes the following actions: A near-term target to reduce Scope 1 and 2 by 60% and Scope 3 emissions by 50% by 2030. A long-term target to reduce Scope 1, 2 and 3 emissions by 90% by 2040. Decarbonizing fleet vehicles and switching to renewable energy tariffs. Partnering with its suppliers to decarbonize and including carbon considerations into its procurement processes. Implementing a 50% reduction in business travel. Creating projects centered around using nature-based solutions to offset residual carbon.
MD

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06:47 EDT Mednax appoints James Swift as COO, Curtis Pickert as Chief Physician Executive - Mednax named James Swift as COO and Curtis Pickert as Chief Physician Executive. Both Swift and Pickert have been with the company for over a decade and have held expanding leadership roles over that time. Swift joined Mednax in 2009 and most recently served as Executive VP and Chief Development Officer. Previously, he served as Regional President of the South Central Region for Pediatrix. Pickert joined Mednax in 2009 and most recently served as Executive VP, Clinical Services Division. Previously, he served as President of the Clinical Services Division, Chief Medical Officer of the Western Division, and Vice President, South Central Region for the company's Pediatrix Division.
CAE

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06:47 EDT CAE reschedules Q4 earnings release - CAE announced that the release of its Q4 and FY22 results will be rescheduled. The company said, "The Company deferred the release of its results from the originally planned date of May 19, 2022 in order to allow the Company's external auditors to complete their final normal course audit procedures. CAE expects to issue the results by June 2, 2022 and will publicly announce a new earnings release and conference call date and time as soon as available."
TGT

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06:46 EDT Target drops 22% to $167.51 after Q1 EPS misses estimates
TMQ

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06:45 EDT Trilogy Metals provides update on Ambler Access Project - Trilogy Metals provided an update on the Ambler Access Project, or AAP, the proposed 211-mile industrial-use-only road from the Upper Kobuk Mineral Projects to the Dalton highway. Yesterday, the United States District Court granted the United States Department of the Interior's, or DOI, motion for voluntary remand without vacatur. The DOI had requested the voluntary remand of the previously issued Joint Record of Decision, or JROD, that authorized a right-of-way across federally managed lands for the Alaska Industrial Development and Export Authority, or AIDEA, and the AAP. Importantly, Judge Gleason also ruled that the Court shall retain jurisdiction over this matter, and the court is requiring that the DOI file a status report with the court within 60 days from the date of the order and every 60 days thereafter. In addition, any party involved in this action may move for a status conference upon a showing of good cause. The DOI had indicated that the remand was necessary because the DOI had identified deficiencies in their analysis of impacts to subsistence uses under ANILCA Section 810 and their consultation with Tribes pursuant to NHPA Section 106.27. They requested a remand in order to supplement the administrative record in these regards. Now that the remand request has been granted by the Court, the Company will continue discussions with its partners, including NANA Regional Corporation, Inc., AIDEA, the Northwest Arctic Borough, the State of Alaska and South32 Limited to determine the impact of the above decision on AIDEA's proposed plan and budget for the 2022 summer field season activities that were previously announced.
CMS

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06:42 EDT CMS Energy to add 300 megawatts of clean energy from two Michigan solar projects - Consumers Energy announced agreements to add 300 megawatts of clean energy - enough to power about 150,000 homes -- from two Michigan solar projects being developed in Genesee and Hillsdale counties. The solar developments are part of the company's Clean Energy Plan to increase renewable energy, eliminate coal electricity by 2025 and achieve net zero carbon emissions by 2040. Both projects are being developed by Ranger Power, a utility-scale solar development company based in Chicago. Consumers Energy would purchase power from Confluence Solar in Genesee County and Heartwood Solar in Hillsdale County. The agreements are being reviewed by the Michigan Public Service Commission. The new solar projects are each 150 megawatts and scheduled to begin operating by year-end 2024. Ranger Power will own and operate the sites.
TFX

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06:36 EDT Teleflex's Manta Vascular Closure Device approved by Health Canada - Teleflex received Health Canada approval for the Manta Vascular Closure Device, the first commercially available biomechanical vascular closure device designed specifically for large bore femoral arterial access site closure. The Manta Device is indicated for closure of femoral arterial access sites while reducing time to hemostasis following the use of 10-20F devices or sheaths in endovascular catheterization procedures. The SAFE MANTA IDE Clinical Trial demonstrated that the Manta Device achieved fast reliable biomechanical closure with rapid hemostasis, with all primary and secondary endpoints met.
DT

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06:35 EDT Dynatrace CFO Kevin Burns to leave at end of calendar year 2022 - Dynatrace announced that Kevin Burns, its CFO, will be leaving at the end of calendar year 2022. Dynatrace has initiated a search for a new CFO, and Burns will work to ensure a smooth transition of his duties once a new CFO is appointed.
TGT

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06:34 EDT Target sees Q2 operating income margin in a wide range centered around 5.3%
GLNG

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06:24 EDT Golar LNG, Snam sign EUR 269M contract for LNG carrier - Snam and Golar LNG signed a contract through which Golar will deliver the existing LNG Carrier "Golar Arctic" as a floating storage and regasification unit, or FSRU, that Snam will install in the port area of Portovesme, in Sardinia, as part of a project to supply the island with energy. The contract, for a total consideration of 269M euros, includes the vessel and the capex for Golar to convert the Golar Arctic into an FSRU with storage capacity for up to 140,000 cubic meters. Further to the full conversion of the vessel, the FSRU will be sold to the Snam Group. Start of activities for the conversion of the ship into an FSRU and related fulfillments are subject to Snam's issuance of a Notice-to-Proceed and further to that the conversion is expected to take about two years for the Golar Arctic to be delivered.
STM

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06:17 EDT STMicroelectronics, SP announce agreement to install district cooling system - STMicroelectronics and SP Group announced the signing of an agreement to install a district cooling system at ST AMK TechnoPark. At an estimated project value of 370M over 20 years, it will be Singapore's largest district cooling system, or DCS, to be implemented for an industrial development when operational in 2025. Under the agreement, SP will design, build, own and operate the DCS, providing chilled-water-as-a-service to meet both the manufacturing and spatial cooling needs of ST. With a cooling capacity of up to 36,000 refrigerant tons, it will help ST achieve 20% savings in cooling-related electricity consumption annually by improving aggregated chiller system efficiency, as well as enable ST to reduce carbon emissions of up to 120,000 tons per year for ST Technopark, equivalent to taking 109,090 cars off the road. This decarbonization is a result of lower energy consumption and an increased capacity to incorporate solar energy and Perfluorocarbons abatement equipment by repurposing more than 4,000 square meters of chiller plant space that will be freed up once the DCS is operational.
FIXX

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06:10 EDT Homology Medicines presents results of gene editing candidate HMI-103 - Homology Medicines presented the mechanism of action and optimization of HMI-103, the nuclease-free gene editing candidate currently in a Phase 1 trial for phenylketonuria - PKU -. HMI-103 utilizes the body's natural DNA repair process to insert a functional copy of the PAH gene into a specific region of the genome. It is designed to provide a permanent DNA correction for PKU by replacing at least one disease-causing allele with a normal gene sequence in edited cells. Also at the American Society of Gene and Cell Therapy Annual Meeting, Homology presented data from its genome-wide integration assays, which confirmed the precision of HR-based integration of HMI-103, including no off-target editing in human hepatocytes in a humanized murine liver model. In addition, Homology shared new data from its GTx-mAb platform showing sustained antibody levels in murine and humanized models. The characterization of AAVHSC16 that has low tropism to the liver was also presented, a novel finding that provides opportunities to target additional diseases with a potentially lower immunogenicity profile. The company believes the new discovery that AAVHSC16 was able to target key tissues such as the CNS, muscle and cardiac tissue following a single I.V. administration, while having a very low affinity for the liver, may enable it to expand into new disease areas.
WATT

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06:07 EDT Energous announces Sekorm as a value-added partner in China - Energous announced Sekorm as a value-added partner in China. Through its partnership with Sekorm, Energous gains access to more industrial Internet of Things design communities, marketing and sales capabilities, and increased awareness of its award-winning WattUp wireless power network technology in China. Energous recently announced approval by the Ministry of Industry and Information Technology in China for IoT applications. Energous' WattUp PowerBridge supports multiple next-generation applications including smart tags, electronic shelf labels, sensors, asset trackers and more.
LLAP

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06:06 EDT Terran Orbital unit awarded contract from DARPA, terms not disclosed - Terran Orbital announced that its subsidiary, PredaSAR Corporation, received a contract award from the Defense Advanced Research Projects Agency under an Other Transaction Authority for Prototype Agreement. Specific terms of the Agreement were not disclosed.
KROS

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06:05 EDT Keros Therapeutics presents results from Phase 1 trial of KER-012 - Keros Therapeutics announced preliminary topline results from Part 1 of its Phase 1 clinical trial evaluating single and multiple ascending doses of KER-012 in healthy postmenopausal volunteers. The ongoing trial is designed as a two-part trial to assess the safety, tolerability and pharmacokinetics of KER-012. KER-012 was generally well tolerated in Part 1 of this trial at dose levels up to 5 mg/kg, the highest dose level tested, when administered as a single dose. There were no discontinuations due to treatment-related adverse events in Part 1. No serious adverse events were reported in Part 1. Additionally, the majority of the adverse events that were observed in Part 1 of this trial were mild in severity. Pharmacokinetic parameters were observed to be generally dose proportional with increasing doses. Maximal target engagement was observed following a single 5 mg/kg dose of KER-012, with a mean 39.6% reduction in follicle-stimulating hormone levels observed on Day 22. Robust increases in markers of bone formation were observed. No clinically meaningful changes in red blood cells or hemoglobin were observed in Part 1. Keros expects to report data from Part 2 of this trial in the second half of 2022. Following the completion of this Phase 1 clinical trial, Keros expects to initiate a Phase 2 clinical trial of KER-012 in patients with pulmonary arterial hypertension, and expects to share the trial design for the Phase 2 clinical trial in early 2023.
TPC

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06:05 EDT Tutor Perini unit awarded $85M United States Coast Guard contract - Tutor Perini announced that its subsidiary, Perini Management Services, has been awarded a task order valued at approximately $85M by the United States Coast Guard, for the design and construction of family housing at Nemetz Park Site, USCG Base Kodiak, in Kodiak, Alaska. The project scope of work includes construction of 50 family housing units in 25 duplex configurations. The project also includes demolition, utilities, roads, sidewalks, and other site improvements. The work will be phased to provide incremental turnover of units for beneficial occupancy. Work is expected to begin immediately with substantial completion anticipated in the third quarter of 2025. The contract value will be included in the company's second-quarter 2022 backlog.