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PTCT | Hot Stocks09:23 EDT PTC Therapeutics announces preliminary data from FIREFISH trial in Type 1 SMA - PTC Therapeutics announced the presentation of early interim data from Part 1, the dose-finding portion of the FIREFISH study. FIREFISH is a two-part seamless, open-label, multi-center study to investigate the safety and efficacy of RG7916 in infants and babies with Type 1 SMA. RG7916 has been safe and well tolerated at all doses and there have been no drug-related safety findings leading to withdrawal. In addition, data on the ability to swallow and requirements for tracheostomy or permanent ventilation, together with overall survival were also presented. Previously published natural history data indicate that in a comparable historic cohort the median age of event-free survival for SMA Type 1 infants to be between 8 and 10.5 months. In addition to the oral presentation, three posters were on display during the Congress: updated pharmacodynamic and safety data from SUNFISH Part 1, preliminary evidence for pharmacodynamic effects of RG7916 in JEWELFISH, and preclinical data demonstrating the relationship between central and peripheral SMN protein increase upon treatment with RG7916. The data presented demonstrate systemic and dose-dependent increase of SMN protein levels. The data from mice and other species suggest that SMN protein level increases seen in the blood of patients following RG7916 treatment reflect SMN protein level increases in the CNS, muscle and other key issues affected in SMA. In addition, RG7916 has been safe and well tolerated at all doses and there have been no drug-related safety findings leading to withdrawal. The U.S. Food and Drug Administration granted orphan drug designation to RG7916 for the treatment of patients with SMA.
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WHR... | Hot Stocks08:11 EDT Week in review: How Trump's policies moved stocks - Catch up on the top industries and stocks that were impacted, or were predicted to be impacted, by the comments, actions and policies of President Trump and his administration with this weekly recap compiled by The Fly: 1. TARIFF ON WASHING MACHINES: On Monday, the Trump Administration announced that it will impose a 20% tariff on the first 1.2M imported large residential washing machines in the first year and a 50% tariff on machines above that number. Commenting on the news, Jeff Fettig, the chairman of U.S. home appliance manufacturer Whirlpool (WHR) praised the President's decision and said: "This announcement caps nearly a decade of litigation and will result in new manufacturing jobs in Ohio, Kentucky, South Carolina and Tennessee. [...] By enforcing our existing trade laws, President Trump has ensured American workers will compete on a level playing field with their foreign counterparts, enabled new manufacturing jobs here in America and will usher in a new era of innovation for consumers everywhere." Conversely, Samsung (SSNLF) said the announcement is a "great loss" for American consumers and workers. "This tariff is a tax on every consumer who wants to buy a washing machine. Everyone will pay more, with fewer choices." 2. TARIFF ON SOLAR IMPORTS: This week, the Trump Administration also announced the President's decision to slap tariffs on imported solar cells. A 30% tariff will be imposed on imported solar cells and modules in the first year, with the tariffs declining to 15% by the fourth year. The tariff allows 2.5 gigawatts of unassembled solar cells to be imported tariff-free in each year. According to Bloomberg, foreign solar panel manufacturers, including China's JinkoSolar Holding (JKS) and JA Solar (JASO), thought that the 30% tariff implemented on U.S. imports by President Donald Trump was "better than expected." The companies had been preparing since October when the U.S. International Trade Commission recommended a 35% tariff. Commenting on the news, Credit Suisse analyst Michael Weinstein notes that the approved solar import tariff was in-line with expectations. The analyst argued that the news is positive for companies exempt from the tariff, notably First Solar and Tesla (TSLA) until now. Conversely, Weinstein pointed out that he expects negative sentiment around Chinese solar manufacturers, such as JinkoSolar and JA Solar, and expects negligible impact to residential solar developers Sunrun (RUN) and Vivint Solar (VSLR). Other companies in the space include, SunPower (SPWR), Canadian Solar (CSIQ), Yingli Green Energy (YGE), Solaredge (SEDG), Enphase Energy (ENPH), Sunrun and Sky Solar (SKYS). 3. MORE EMPLOYEE BONUSES: On Tuesday, Disney (DIS) announced that over 125,000 eligible employees will receive a one-time $1,000 cash bonus. The announcement followed one from JPMorgan (JPM), which this morning announced a $20B, five-year comprehensive investment in its employees as well as branch expansion. The bank plans to boost wages to $15-$18 an hour for 22,000 workers and intends to open up 400 new Chase branches in new cities and states. The same day, Verizon Communications (VZ) CEO Lowell McAdam said on CNBC that his company is giving all non-executive employees 50 shares of stock following tax reform in the U.S. 4. VEHICLE-EMISSIONS RULES: Earlier this week, The Wall Street Journal reported that California regulators and Trump administration officials have met to discuss changes to controversial vehicle-emissions rules in effort to prevent a legal battle over future regulation. The California Air Resources Board has supported current federal rules that require automakers to cut emissions so vehicles sold average more than 50 miles a gallon by 2025, but the Trump administration is looking to see if the state is open to relaxing future emissions and mileage goals. Publicly traded companies in the space include Daimler AG (DDAIF), Fiat Chrysler (FCAU), Ford (F), General Motors (GM), Honda (HMC), Nissan (NSANY), Toyota (TM), Volkswagen (VLKAY) and Tesla (TSLA). "Week in Review" is The Fly's weekly recap of its recurring series of "Trump Effect" exclusive stories.
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