Stockwinners Market Radar for January 20, 2018 - Earnings, Upgrades downgrades, option trades, Best Stock Advisory Service

15:26 EDT Opdivo, Yervoy combo demonstrates activity in patients with dMMR, MSI-H mCRC - Bristol-Myers Squibb announced new data from a cohort of the phase 2 CheckMate -142 trial evaluating Opdivo and Yervoy for the treatment of patients with DNA mismatch repair deficient or microsatellite instability-high metastatic colorectal cancer. With a median of 13.4 months of follow-up, the primary endpoint of objective response rate per investigator assessment was 55%. Responses were durable, with median duration of response not yet reached and 94% of responses ongoing at time of data cutoff. The overall survival rate at one year was 85%, and median OS was not yet reached. Grade 3-4 treatment-related adverse events occurred in 32% of patients receiving the Opdivo plus Yervoy combination. Patients received mCRC combination dosing of Opdivo plus Yervoy every three weeks for four doses, followed by Opdivo every two weeks until disease progression, death or unacceptable toxicity.

15:17 EDT Array BioPharma updates results from BEACON Phase 3 trial - Array BioPharma and Pierre Fabre announced updated results from the 30 patient safety lead-in of the Phase 3 BEACON CRC trial evaluating the triplet combination of encorafenib, a BRAF inhibitor, binimetinib, a MEK inhibitor and cetuximab, an anti-EGFR antibody, in patients with BRAF-mutant metastatic colorectal cancer whose disease has progressed after one or two prior regimens. The data were presented at the ASCO 2018 Gastrointestinal Cancers Symposium in San Francisco, California. In patients with the BRAFV600E mutation, the estimated median progression-free survival at the time of analysis was 8 months. The confirmed overall response rate in patients with the BRAFV600E mutation was 48%, and 3 patients achieved complete responses. Further, the ORR was 62% in the 16 patients who received only one prior line of therapy. These data represent substantial improvements compared to several separate historical published standard of care benchmarks for this population. In the safety lead-in, the triplet combination was generally well-tolerated. Two patients discontinued treatment due to adverse events with only one of these considered related to treatment. The most common grade 3 or 4 AEs seen in at least 10% of patients were fatigue, urinary tract infection, increased aspartate aminotransferase and increased blood creatine kinase. All patients with elevated baseline levels of the tumor markers CEA and CA19-9 had a reduction from baseline, with similar and substantial reductions across both markers in patients with objective responses and those with stable disease. The enrollment in the randomized portion of the BEACON CRC trial is ongoing.

15:10 EDT Teck Resources announces Elkview incident - Teck Resources announced that there has been a significant pressure event at the dryer at Teck's Elkview mine. There were no adverse health or environmental impacts. Work is ongoing to assess the extent of the damage and the potential impact on production. Elkview continues to operate at a reduced production rate using the unaffected facilities at the mine. It is too soon to estimate the extent of any downtime or loss of production as a result of the event.

08:24 EDT Week in review: How Trump's policies moved stocks - Catch up on the top industries and stocks that were impacted, or were predicted to be impacted, by the comments, actions and policies of President Trump and his administration with this weekly recap compiled by The Fly: 1. APPLE: On Wednesday, Apple (AAPL) announced that it plans to establish a campus in a new location, which will initially house technical support for customers. The location of this new facility will be announced later in the year. The iPhone maker expects to invest over $30B in capital expenditures in the U.S. over the next five years and create over 20,000 new jobs through hiring at existing campuses and opening a new one. The company also informed its workers that it will issue a bonus of $2,500 worth of restricted stock units following the introduction of the new U.S. tax law, according to Bloomberg. Following the news, President Donald Trump tweeted, "I promised that my policies would allow companies like Apple to bring massive amounts of money back to the United States. Great to see Apple follow through as a result of TAX CUTS. Huge win for American workers and the USA!" 2. AIRBUS: Airbus (EADSY) CEO Tom Enders took aim at the Trump administration, accusing it of protectionism, while criticizing competitor Boeing (BA) for exploiting such sentiments, the Wall Street Journal reported earlier this week. Speaking at an event in London on Monday sponsored by the U.K.'s aerospace and defense industry trade body, Enders said that the U.S. "is no longer fighting for free trade" and claimed that the Trump administration was taking actions to close the U.S. market to foreign rivals, the report added. 3. VERIZON: In a regulatory filing on Wednesday, Verizon (VZ) said it estimates that the enactment of the Tax Cuts and Jobs Act will result in a one-time reduction in net deferred income tax liabilities of approximately $16.8B, due primarily to the re-measurement of U.S. deferred tax liabilities at the lower 21% U.S. federal corporate income tax rate. This impact will be reflected in income from continuing operations which will increase the company's earnings for Q4 and year ending December 31, 2017, but will not have any impact on the 2017 statement of cash flows. For the year ending December 31, 2017, the impact of the TCJA to Verizon's earnings per share is estimated to be approximately $4.10. 4. FAKE NEWS AWARDS: On Wednesday night, President Donald Trump released his "Highly-Anticipated 2017 Fake News Awards," listing the eleven "winners." Among the news outlets mentioned in the awards were The New York Times (NYT), Time Warner's (TWX) CNN, Disney's (DIS) ABC News, and Time (TIME). Note that Time is being acquired by Meredith Corporation (MDP), but the deal has not yet closed. Also mentioned were privately held Newsweek, which is owned by IBT Media, and the Washington Post, which is owned by Amazon (AMZN) founder Jeff Bezos. 5. BANKS: Banks continued their earnings reporting this week, with Bank of America (BAC) and Goldman Sachs (GS) each posting their results on Wednesday morning. Excluding the impact of tax legislation, both reported earnings that topped consensus forecasts. For BofA, net income of $2.4B, or 20c per diluted share, included a charge of $2.9B, or 27c per diluted share, related to the Tax Cuts and Jobs Act. Goldman Sachs, meanwhile, recorded $4.4B of income tax expense related to tax reform. Following Bank of New York Mellon's (BK) fourth quarter earnings report Thursday, the bank's executives said that nearly all of this year's benefits from the new U.S. tax law will go to technology upgrades and its workers instead of shareholders. Such moves, according to the Wall Street Journal, include a raise in the minimum wage to $15 an hour starting March 1 mostly for employees in the company's operations unit. The wage increase will affect roughly 1,000 of the bank's 52,500 employees, the Journal noted. 6. PRICE TARGETS: To reflect the new tax reform, Wells Fargo increased the price targets for Dollar Tree (DLTR), Celanese (CE), LyondellBasell (LYB), Westlake Chemical (WLKP), Monsanto (MON), Trinseo (TSE), and National Vision (EYE), while Credit Suisse upped its targets for E-Trade (ETFC), LPL Financial (LPLA), TD Ameritrade (AMTD), Charles Schwab (SCHW), Alliance Data (ADS), Fiserv (FISV), FleetCor (FLT), Blackhawk (HAWK), and MasTec (MTZ). "Week in Review" is The Fly's weekly recap of its recurring series of "Trump Effect" exclusive stories.