Stockwinners Market Radar for May 14, 2017 - Earnings, Upgrades downgrades, option trades, Best Stock Advisory Service |
WDC... | Hot Stocks20:00 EDT On The Fly: Top five weekend stock stories - Catch up on the weekend's top five stories with this list compiled by The Fly: 1. Western Digital (WDC) announced the launch of arbitration proceedings against Toshiba (TOSBF) over the Japanese conglomerate's attempted sale of its memory chip business, which Western has consistently said infringes on their joint venture agreement. 2. GlaxoSmithKline (GSK) plans to buy out Novartis' (NVS) 36.5% stake in its consumer healthcare business, according to the Sunday Times. 3. This weekend's medical conferences brought data from companies including Genomic Health (GHDX), Intellia (NTLA), Editas Medicine (EDIT) and Veru (FHCO). 4. Disney's (DIS) superhero sequel "Guardians Of The Galaxy Vol. 2" topped the box offices in its second weekend as Fox (FOX) comedy "Snatched" and Time Warner (TWX) fantasy action film "King Arthur: Legend Of The Sword" underperformed against expectations. 5. Analog Devices (ADI), Air Lease (AL), Houghton Mifflin (HMHC), Revlon (REV) and JD.com (JD) saw positive mention in Barron's, while Whole Foods (WFM) and Snap (SNAP) were discussed cautiously.
|
WDC... | Hot Stocks17:59 EDT Western Digital initiates arbitration against Toshiba over attempted chip sale - Western Digital (WDC) announced that several of its SanDisk subsidiaries have filed a request for arbitration with the ICC International Court of Arbitration related to three NAND flash-memory joint ventures operated with Toshiba (TOSBF). The arbitration demand seeks, among other things, an order requiring Toshiba to unwind the transfer of joint venture interests to Toshiba Memory, and injunctive relief preventing Toshiba from further breaching the JV agreements by transferring its JV interests without SanDisk's consent. Per the joint venture agreements, the arbitration will take place in San Francisco. "SanDisk did not consent to the transfer to Toshiba Memory, and Toshiba has now repudiated any intention to obtain SanDisk's consent before selling Toshiba Memory to the winning bidder of the auction," the company noted. Western Digital CEO Steve Milligan commented, "We continue to be actively engaged in discussions with Toshiba's stakeholders to ensure that they are fully aware of our joint venture rights and of our desire to work with Toshiba to achieve a favorable outcome for all parties... SanDisk and Toshiba agreed to protect their interests in the joint ventures by prohibiting transfers without the consent of the other party. Toshiba's attempt to spin out its joint venture interests into an affiliate and then sell that affiliate is explicitly prohibited without SanDisk's consent. Seeking relief through mandatory arbitration was not our first choice in trying to resolve this matter. However, all of our other efforts to achieve a resolution to date have been unsuccessful."
|
ABBV JNJ | Hot Stocks17:19 EDT AbbVie reports pooled data from three Phase 3 Imbruvica studies - AbbVie (ABBV) announced results from an analysis of data pooled from three Phase 3 studies evaluating Imbruvica use in patients with high-risk chronic lymphocytic leukemia/small lymphocytic lymphoma: RESONATE, RESONATE-2 and HELIOS. In the analysis, CLL/SLL patients with genomic abnormalities that typically put them at high risk for poor outcomes achieved higher complete response rates and overall response rates, as well as longer progression free survival at 24 months and overall survival at 30 months when treated with Imbruvica. The data will be presented at the International Workshop on Chronic Lymphocytic Leukemia biennial meeting. Specifically, the ORR in patients treated with Imbruvica was 89% in unmutated IGHV, 88% in del 11q, 86% in trisomy 12 and 87% in CK, with patients achieving a CR rate of 22% in unmutated IGHV, 18% in del 11q, 25% in trisomy 12 and 10% in CK. At 24 months, in patients treated with Imbruvica, PFS was 78% in unmutated IGHV, 82% in del 11q, 77% in trisomy 12 and 76% in CK. In patients treated with Imbruvica, at 30 months, OS was 88% in unmutated IGHV, 93% in del 11q, 89% in trisomy 12 and 84% in CK. In each subgroup, PFS, OS, ORR and CR rates trended higher in Imbruvica-treated patients versus comparator-treated patients, regardless of genomic factors. In Imbruvica-treated patients, unmutated IGHV, del 11q, trisomy 12 or CK were generally not associated with shorter PFS or OS, or decreased ORR or CR rate. Further, in Imbruvica-treated patients, del 11q was associated with a trend of longer PFS and OS and trisomy 12 with increased CR rate. In a multivariate analysis, ibrutinib-treated patient outcomes in those only having received one or more prior lines of therapy versus treatment in the first-line was associated with shorter PFS and OS. Adverse events were similar in patients with or without genomic factors, and reflect a median treatment exposure of 19-20 months for Imbruvica-treated patients and 5-10 months for comparator. Discontinuation due to AEs ranged from 8%-15% in Imbruvica-treated patients and 13%-17% in comparator. Imbruvica, a first-in-class Bruton's tyrosine kinase inhibitor, is jointly developed and commercialized by AbbVie and Johnson & Johnson's (JNJ) Janssen.
|
DIS... | Hot Stocks17:05 EDT Box Office Battle: 'Guardians Of The Galaxy' wins weekend as 'King Arthur' flops - Disney's (DIS) "Guardians Of The Galaxy Vol. 2" earned $63M in the U.S. over the May 14 weekend, dipping about 57% from its opening numbers and falling slightly short of a $65M-$70M forecast. BOX OFFICE RUNNERS-UP: Fox's (FOX) "Snatched" opened at $17.5M, disappointing expectations for $20M-$21M. The Amy Schumer-led comedy was scored B in CinemaScore polls and holds a Rotten Tomatoes rating of 36%. Taking third place, Time Warner's (TWX) "King Arthur: Legend Of The Sword" debuted at $14.7M domestically versus estimates of $20M-$25M. The film, a Guy Ritchie-directed retelling of the Arthurian legend starring Charlie Hunnam and Jude Law, received a B+ in audience polls from CinemaScore, holds a 28% critics rating on Rotten Tomatoes, and was produced with a reported budget of $175M. In overseas markets, "Arthur" took $29M. Rounding out the top five, Comcast's (CMCSA) "The Fate Of The Furious" added $5.3M in its fifth weekend while Fox's "The Boss Baby" grossed $4.6M in its seventh. Also of note was the foreign launch of Fox's "Alien: Covenant," which saw the extraterrestrial horror earn $42M ahead of its May 19 debut in the U.S. Other publicly traded companies in filmmaking include Lionsgate (LGF.A), Sony (SNE) and Viacom (VIA).
|
NVS | Hot Stocks14:55 EDT Novartis receives orphan designation for malaria treatment - The FDA has granted Novartis orphan designation for malaria treatment "2-amino-1-pyrazin-7(8H)-yl)-ethanone diphosphate." The designation was granted May 11, according to an online notice from the agency. Reference Link
|
NTWK | Hot Stocks14:42 EDT NetSol postpones Q3 report, says auditor requires additional review time - NetSol Technologies announced Sunday that it has postponed its Q3 earnings announcement and conference call originally scheduled for May 15. The company now plans to report on May 22. "NETSOL's delay in announcing its results is due to the additional time the company's new independent auditor needs to finalize its review of the company's fiscal Q3 and nine months ended March 31, 2017 financial results. The company does not anticipate this delay will lead to any adverse change in its financial results," the company said. NETSOL's quarterly report on Form 10-Q for its Q3 will also not be timely filed.
|
FHCO | Hot Stocks14:33 EDT Veru reports Phase 4 data on PREBOOST product - Veru Healthcare announced "positive" results from a Phase 4 clinical study of its proprietary product PREBOOST for the management of premature ejaculation. Data showed that PREBOOST wipes statistically and significantly improved both objective and subjective symptoms of PE when compared to placebo wipes. Results were selected for inclusion in the American Urological Association's Annual Meeting. Specifically, the study met its primary endpoint of change in average Intravaginal Ejaculatory Latency Time at two months, as well as secondary outcomes of change in questionnaire assessments including global rating of distress, medication assessment and Index of Premature Ejaculation. After treatment with PREBOOST, 82 percent of men were no longer considered to have PE while being treated and reported a statistically significant better sense of ejaculation control, confidence, satisfaction, sexual pleasure, increased length of intercourse and reduced frustration. Treatment was well tolerated and no transference of product was reported. Two treated men experienced adverse events, including mild headache and back pain and mild irritation on the penis, which resolved spontaneously. "These Phase 4 data represent the first clinical study ever to show clinical data of an OTC product for the management of premature ejaculation," the company noted.
|
EDIT AGN | Hot Stocks14:29 EDT Editas: Pre-clinical trial demonstrates first in-vivo primate retina editing - Editas Medicine (EDIT) announced results Saturday from a pre-clinical study demonstrating what the company called the first achievement of efficient editing of the CEP290 gene in the retina of non-human primates. "The results of this study further reinforce Editas Medicine's belief in the transformative potential of its candidate medicine for Leber Congenital Amaurosis type 10, an inherited retinal degenerative disease that appears in childhood and leads to blindness," the company noted. The company reported the data at the Annual Meeting of the American Society of Gene & Cell Therapy. In the study, two guide RNAs and S. aureus Cas9 expressed under the control of a photoreceptor-specific promoter were delivered in a single, subretinally-injected adeno-associated virus at two different doses. Retinal tissue and genomic DNA were taken from within the sub-macular bleb region at six and 13 weeks and analyzed using Editas' novel sequencing method, UDiTaS, to quantify all editing events. Gene editing was demonstrated to be dose and time dependent. Editing rates were measured directly as a percentage of all alleles in total genomic DNA taken from the retinas of non-human primates, which included both photoreceptor cells and other cell types. Editing rates were also projected based on additional analyses which demonstrated that Cas9 expression was limited to photoreceptor cells, which are the target cells for LCA10 treatment. For animals treated with the higher dose, the projected productive editing rate may be as high as 50 percent in photoreceptor cells, based on directly measured editing of 15 percent in total genomic DNA and an estimate for the proportion of cells represented by photoreceptors. "Based on analyses presented today, we believe that we were successful in editing the vast majority photoreceptors using a primate-specific candidate that shares critical design and construction features with our clinical candidate," said Charles Albright, Chief Scientific Officer. In March, Editas and Allergan (AGN) entered into a research and development alliance under which Allergan received exclusive access and the option to license up to five of Editas' genome-editing candidate medicines for ocular diseases, including its product candidate for LCA10.
|
NTLA | Hot Stocks14:23 EDT Intellia reports data on CRISPR/Cas9 platform in rat models - Intellia Therapeutics presented an update on its long-term mouse genome editing and delivery studies and shared new, first-time data in rat models demonstrating consistent dose-dependent editing at the American Society of Gene & Cell Therapy's Annual Meeting. Data included: Six-month mouse study data demonstrating both durability and high editing efficiency in vivo, with approximately 70 percent editing at the target DNA site with a single intravenous dose. A 97 percent reduction of serum transthyretin protein levels also was sustained. In addition, robust, dose-responsive lipid nanoparticle-mediated editing of the TTR gene in rat livers following single intravenous administration; up to 66 percent editing at the target DNA site and up to 91 percent reduction in serum TTR protein levels. "Data from the additional rat study further validates the in vivo CRISPR/Cas9 platform using Intellia's proprietary LNP delivery system," said David Morrissey, senior vice president, Platform and Delivery Technology. "In both species, we saw unprecedented in vivo liver editing results and consistent delivery of CRISPR/Cas9 with systemic administration using LNPs, while also showing the ability to expand our studies in larger species."
|
GHDX | Hot Stocks14:21 EDT Genomic Health reports data from two Oncotype DX GPS analyses - Genomic Health on Saturday announced results from two Oncotype DX Genomic Prostate Score test analyses based on a prospective, multi-center, 1,200-patient study. Results of one analysis, presented at the American Urological Association 2017 Annual Meeting, "prospectively validate" the GPS test as an independent predictor of adverse pathology as a measure of tumor aggressiveness in men with localized prostate cancer, the company said. A second analysis, presented at AUA and published online in Urology, reinforces that the GPS test significantly increases use and persistence on active surveillance. Regarding the interim analysis of the 1,200-patient study, results from 258 patients demonstrated that use of the GPS test changed initial treatment recommendations for 23 percent of patients, which is consistent with previously reported studies. Sixty-two percent of the GPS-tested patient population selected active surveillance compared to 40 percent of the men who did not receive the test. Of men who selected active surveillance initially, the vast majority - 89 percent - remained on active surveillance at one year based on personalized genomic information from the GPS test. Turning the prospective validation study, the company said the initial findings from 122 patients across 19 centers "demonstrated that the GPS result was a strong and independent predictor of adverse pathology across very low-, low- and intermediate-risk patients. Importantly, these prospective validation study results are consistent with previously published studies based on retrospective patient cohorts."
|
SO... | Hot Stocks14:04 EDT Southern Co unit, Westinghouse reach service agreement in principle for Vogtle - Southern Company's (SO) Georgia Power and Toshiba's (TOSBF) Westinghouse announced Friday they have, in principle, reached a new service agreement for the Vogtle nuclear expansion which allows for the transition of project management from Westinghouse to Southern Nuclear and Georgia Power once the current engineering, procurement and construction contract is rejected in Westinghouse's bankruptcy proceeding. The interim assessment agreement will remain in place until June 3 while the new service agreement is finalized and all approvals are obtained. During this time, work will continue at the site and an orderly transition of project management will begin.
|
POR | Hot Stocks14:02 EDT Portland General Electric says suspends permitting processes for new sites - Portland General Electric submitted a letter Friday to the Oregon Department of Energy and another to the Oregon Department of Environmental Quality asking for suspension of the utility's request for amendment of the site certificate for the Carty Generating Station near Boardman as well as a related air permit application. "The amendment and permit, if approved, would have allowed for the construction of two new generating units at Carty, if the units were selected as the least cost/lowest risk option in a future competitive bidding process for new generating resources. PGE's request for the amendment was driven by the need to insure that the company has a viable option to secure a cost-effective dispatchable generation resource to provide reliable service to customers... If the company is able to secure capacity through bilateral negotiations PGE will seek approval of the agreements from the Oregon Public Utility Commission along with a waiver to competitive bidding guidelines as necessary. The company may also propose a competitive request for proposals to acquire any additional needed capacity resources not acquired through the bilateral negotiations," the company explained. "We're currently in bilateral negotiations to acquire dispatchable resources to meet our customers' energy needs. It's appropriate for us to suspend the permitting process at Carty until we complete these negotiations," said Jim Piro, PGE's CEO.
|